| UniProt Protein Function: | PPP2R5C: a regulatory subunit of PP2A that might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.Three alternatively spliced human isoforms have been described. |
| UniProt Protein Details: | Protein type:Protein phosphatase, regulatory subunit; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 14q32.31 Cellular Component: protein phosphatase type 2A complex; nucleus; chromosome, pericentric region Molecular Function:protein binding; protein phosphatase type 2A regulator activity Biological Process: negative regulation of cell proliferation; proteasomal ubiquitin-dependent protein catabolic process; regulation of catalytic activity; signal transduction; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis |
| NCBI Summary: | The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13362 |
| NCBI GenInfo Identifier: | 116241235 |
| NCBI Gene ID: | 5527 |
| NCBI Accession: | Q13362.3 |
| UniProt Secondary Accession: | Q13362,Q14391, Q15060, Q15174, Q6ZN33, B4DYJ8, B5BUA5 F5GWP3, |
| UniProt Related Accession: | Q13362 |
| Molecular Weight: | 524 |
| NCBI Full Name: | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform |
| NCBI Synonym Full Names: | protein phosphatase 2, regulatory subunit B', gamma |
| NCBI Official Symbol: | PPP2R5C |
| NCBI Official Synonym Symbols: | B56G; PR61G |
| NCBI Protein Information: | serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform; B' alpha regulatory subunit; PP2A B subunit isoform B'-gamma; PP2A B subunit isoform R5-gamma; PP2A B subunit isoform B56-gamma; PP2A B subunit isoform PR61-gamma; renal carcinoma antigen NY-REN-29; protein phosphatase 2, regulatory subunit B', gamma isoform; protein phosphatase 2, regulatory subunit B (B56), gamma isoform |
| UniProt Protein Name: | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform |
| UniProt Synonym Protein Names: | PP2A B subunit isoform B'-gamma; PP2A B subunit isoform B56-gamma; PP2A B subunit isoform PR61-gamma; PP2A B subunit isoform R5-gamma; Renal carcinoma antigen NY-REN-29 |
| Protein Family: | Serine/threonine-protein phosphatase |
| UniProt Gene Name: | PPP2R5C |
| UniProt Entry Name: | 2A5G_HUMAN |
