| UniProt Protein Function: | PPIF: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the cyclophilin-type PPIase family. |
| UniProt Protein Details: | Protein type:EC 5.2.1.8; Isomerase; Mitochondrial Chromosomal Location of Human Ortholog: 10q22.3 Cellular Component: membrane; mitochondrial matrix; mitochondrial proton-transporting ATP synthase complex Molecular Function:peptidyl-prolyl cis-trans isomerase activity; protein binding Biological Process: negative regulation of apoptosis; negative regulation of ATPase activity; regulation of mitochondrial membrane permeability |
| NCBI Summary: | The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P30405 |
| NCBI GenInfo Identifier: | 231968 |
| NCBI Gene ID: | 10105 |
| NCBI Accession: | P30405.1 |
| UniProt Secondary Accession: | P30405,Q2YDB7, Q5W131, |
| UniProt Related Accession: | P30405 |
| Molecular Weight: | 16,541 Da |
| NCBI Full Name: | Peptidyl-prolyl cis-trans isomerase F, mitochondrial |
| NCBI Synonym Full Names: | peptidylprolyl isomerase F |
| NCBI Official Symbol: | PPIF |
| NCBI Official Synonym Symbols: | CYP3; CypD; CyP-M; Cyp-D |
| NCBI Protein Information: | peptidyl-prolyl cis-trans isomerase F, mitochondrial |
| UniProt Protein Name: | Peptidyl-prolyl cis-trans isomerase F, mitochondrial |
| UniProt Synonym Protein Names: | Cyclophilin D; CyP-D; CypD; Cyclophilin F; Mitochondrial cyclophilin; CyP-M; Rotamase F |
| Protein Family: | Peptidyl-prolyl cis-trans isomerase |
| UniProt Gene Name: | PPIF |
| UniProt Entry Name: | PPIF_HUMAN |
