Description
| Product Name: | Porcine Growth Hormone Recombinant Protein |
| Product Code: | RPPB0341 |
| Size: | 0.5mg |
| Species: | Porcine |
| Target: | Growth Hormone |
| Synonyms: | GH1, GH, GHN, GH-N, hGH-N,Pituitary growth hormone, Growth hormone 1, Somatotropin, pST. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The Growth-hormone (1 mg/ml) was lyophilized after extensive dialyses against 0.34 mg sodium phosphate buffer (0.02 mg sodium phosphate monobasic & 0.32 mg sodium phosphate dibasic). |
| Solubility: | It is recommended to reconstitute the lyophilized pST in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized GH although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Somatotropin should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 98.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | The sequence of the first five N-terminal amino acids was determined and was found to be Phe-Pro-Ala-Met-Pro |
| Biological Activity: | Somatotropin contains 3 units/mg. |
GH is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.
Porcine-Somatotropin Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 190 amino acids and having a molecular mass of 21730 Dalton. Growth Hormone is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P01248 |
| NCBI GenInfo Identifier: | 134715 |
| NCBI Gene ID: | 396884 |
| NCBI Accession: | P01248.2 |
| UniProt Secondary Accession: | P01248,Q28958, Q29045 |
| UniProt Related Accession: | P01248 |
| Molecular Weight: | 24,429 Da |
| NCBI Full Name: | Somatotropin |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | GH1�� |
| NCBI Official Synonym Symbols: | GH; pGH�� |
| NCBI Protein Information: | somatotropin |
| UniProt Protein Name: | Somatotropin |
| UniProt Synonym Protein Names: | Growth hormone |
| Protein Family: | Envelope glycoprotein |
| UniProt Gene Name: | GH1�� |
| UniProt Entry Name: |
