Description
| 抗体名: | POLB Antibody (PACO06431) |
| 抗体コード: | PACO06431 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | ELISA:1:10000, WB:1:500-1:2000, IHC:1:100-1:300 |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Synthesized peptide derived from the C-terminal region of human DNA pol β . |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot analysis of K562 cells using DNA pol beta Polyclonal Antibody. |
 | Western Blot analysis of K562 cells using DNA pol beta Polyclonal Antibody. |
| シノニム: | POLB; DNA polymerase β |
| UniProt Protein Function: | POLB: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. Monomer. Interacts with APEX1, HUWE1/ARF-BP1, STUB1/CHIP and USP47. Belongs to the DNA polymerase type-X family. |
| UniProt Protein Details: | Protein type:EC 2.7.7.7; Transferase; Lyase; DNA replication; DNA repair, damage Chromosomal Location of Human Ortholog: 8p11.2 Cellular Component: nucleoplasm; microtubule; spindle microtubule; cytoplasm; nucleus Molecular Function:protein binding; enzyme binding; metal ion binding; microtubule binding; damaged DNA binding; DNA-directed DNA polymerase activity; lyase activity Biological Process: base-excision repair, gap-filling; neuron apoptosis; response to ethanol; DNA damage response, signal transduction resulting in induction of apoptosis; base-excision repair; pyrimidine dimer repair; nucleotide-excision repair, DNA gap filling; DNA repair; DNA-dependent DNA replication; response to DNA damage stimulus |
| NCBI Summary: | The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011] |
| UniProt Code: | P06746 |
| NCBI GenInfo Identifier: | 4505931 |
| NCBI Gene ID: | 5423 |
| NCBI Accession: | NP_002681.1 |
| UniProt Related Accession: | P06746 |
| Molecular Weight: | ~ 38kDa |
| NCBI Full Name: | DNA polymerase beta |
| NCBI Synonym Full Names: | DNA polymerase beta |
| NCBI Official Symbol: | POLB |
| NCBI Protein Information: | DNA polymerase beta |
| UniProt Protein Name: | DNA polymerase beta |
| UniProt Gene Name: | POLB |
| UniProt Entry Name: | DPOLB_HUMAN |
| Antibodies | ELISA Kits |
| Anti-POLB Antibody (CAB1681)[KO Validated] | DNA Polymerase beta Colorimetric Cell-Based ELISA Kit |
| Anti-DNA Polymerase beta Antibody (CAB2412) | |
| POLB Antibody (PACO11341) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
