Description
| 抗体名: | PITRM1 Antibody (PACO44360) |
| 抗体コード: | PACO44360 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Recombinant Human Presequence protease, mitochondrial protein (758-1037AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: PITRM1 antibody at 2.42µg/ml. Lane 1: Mouse placenta tissue. Lane 2: A549 whole cell lysate. Lane 3: Rat gonad tissue. Lane 4: Mouse kidney tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 118, 107 kDa. Observed band size: 118, 50 kDa.. |
 | Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO44360 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO44360 at dilution of 1:100. |
| バックグラウンド: | ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid β A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. |
| シノニム: | Presequence protease, mitochondrial (hPreP) (EC 3.4.24.-) (Pitrilysin metalloproteinase 1) (Metalloprotease 1) (hMP1), PITRM1, KIAA1104 MP1 |
| UniProt Protein Function: | PITRM1: ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Belongs to the peptidase M16 family. PreP subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Mitochondrial; Protease; EC 3.4.24.-; Activator Chromosomal Location of Human Ortholog: 10p15.2 Cellular Component: mitochondrial matrix; mitochondrion Molecular Function:enzyme activator activity; metalloendopeptidase activity; zinc ion binding Biological Process: protein processing; proteolysis |
| UniProt Code: | Q5JRX3 |
| NCBI GenInfo Identifier: | 485956568 |
| NCBI Gene ID: | 10531 |
| NCBI Accession: | Q5JRX3.3 |
| UniProt Secondary Accession: | Q5JRX3,O95204, Q2M2G6, Q4VBR1, Q5JRW7, Q7L5Z7, Q9BSI6 Q9BVJ5, B3KMJ6, B4E0J8, C9JSL2, E7ES23, |
| UniProt Related Accession: | Q5JRX3 |
| Molecular Weight: | 106,065 Da |
| NCBI Full Name: | Presequence protease, mitochondrial |
| NCBI Synonym Full Names: | pitrilysin metallopeptidase 1 |
| NCBI Official Symbol: | PITRM1 |
| NCBI Official Synonym Symbols: | MP1; PreP |
| NCBI Protein Information: | presequence protease, mitochondrial |
| UniProt Protein Name: | Presequence protease, mitochondrial |
| UniProt Synonym Protein Names: | Pitrilysin metalloproteinase 1; Metalloprotease 1; hMP1 |
| UniProt Gene Name: | PITRM1 |
| UniProt Entry Name: | PREP_HUMAN |
