Description
| 抗体名: | PI4K2A Antibody (PACO11227) |
| 抗体コード: | PACO11227 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Human PI4K2A |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| 精製方法: | Antigen Affinity purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | phosphatidylinositol 4-kinase type 2 alpha;PI4K2A;DKFZp761G1923;PI4KII;PIK42A;RP11-548K23.6 ; |
| UniProt Protein Function: | PI4K2A: Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells. Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily. |
| UniProt Protein Details: | Protein type:EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 10q24 Cellular Component: Golgi apparatus; neuron projection; mitochondrion; synaptic vesicle membrane; lysosomal membrane; integral to plasma membrane; dendrite; perikaryon; cytosol; lipid raft; presynaptic membrane; cell soma; membrane; early endosome membrane; intrinsic to membrane; cytoplasmic vesicle; cell junction; endosome Molecular Function:protein binding; 1-phosphatidylinositol 4-kinase activity; magnesium ion binding; ATP binding Biological Process: phosphoinositide phosphorylation; phospholipid metabolic process; basophil degranulation; phosphatidylinositol biosynthetic process |
| NCBI Summary: | Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs (Barylko et al., 2001 [PubMed 11244087]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9BTU6 |
| NCBI GenInfo Identifier: | 74752344 |
| NCBI Gene ID: | 55361 |
| NCBI Accession: | Q9BTU6.1 |
| UniProt Secondary Accession: | Q9BTU6,Q9NSG8, D3DR59, |
| UniProt Related Accession: | Q9BTU6 |
| Molecular Weight: | 479 |
| NCBI Full Name: | Phosphatidylinositol 4-kinase type 2-alpha |
| NCBI Synonym Full Names: | phosphatidylinositol 4-kinase type 2 alpha |
| NCBI Official Symbol: | PI4K2A |
| NCBI Official Synonym Symbols: | PI4KII; PIK42A |
| NCBI Protein Information: | phosphatidylinositol 4-kinase type 2-alpha; phosphatidylinositol 4-kinase type II-alpha; phosphatidylinositol 4-kinase type II (PI4KII) |
| UniProt Protein Name: | Phosphatidylinositol 4-kinase type 2-alpha |
| UniProt Synonym Protein Names: | Phosphatidylinositol 4-kinase type II-alpha |
| Protein Family: | Phosphatidylinositol 4-kinase |
| UniProt Gene Name: | PI4K2A |
| UniProt Entry Name: | P4K2A_HUMAN |
