The Phospho-AXL (Y702) Monoclonal Antibody is a cutting-edge tool for researchers studying AXL, a receptor tyrosine kinase known for its role in cell signaling pathways and cancer progression. This antibody, produced using state-of-the-art technology, specifically targets the phosphorylated form of AXL at the Y702 site, enabling precise detection and analysis in various experimental settings. AXL is a key player in mediating processes such as cell growth, survival, and migration, making it a promising target for therapeutic intervention in cancer and other diseases.
The Phospho-AXL (Y702) Monoclonal Antibody opens up new avenues for investigating the role of AXL in tumor development and progression, as well as its potential as a prognostic marker or therapeutic target in personalized medicine approaches. With its high specificity and reliability, this antibody is a valuable tool for researchers in the fields of oncology and molecular biology seeking to deepen their understanding of AXL signaling and its implications for disease mechanisms and treatment strategies.
Product Name:
Phospho-Axl-Y702 Monoclonal Antibody
SKU:
CABP1427
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic phosphorylated peptide around Y702 of human Axl (NP_068713.2).
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:500 - 1:1000
Synonyms:
ARK; UFO; JTK11; Tyro7; Phospho-Axl-Y702
Positive Sample:
A-549
Conjugate:
Unconjugated
Cellular Localization:
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
98kDa
Observed MW:
138kDa
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. The encoded protein acts as a host cell receptor for multiple viruses, including Marburg, Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus.
Purification Method:
Affinity purification
Gene ID:
558
Clone Number:
ARC58385
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of A-549, using Phospho-Axl-Y702 Rabbit mAb (CABP1427) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
