Description
| 抗体名: | PHC1 Antibody, FITC conjugated (PACO46112) |
| 抗体コード: | PACO46112 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | Recombinant Human Polyhomeotic-like protein 1 protein (142-225AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | FITC |
| バックグラウンド: | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression. |
| シノニム: | Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1), PHC1, EDR1 PH1 |
| UniProt Protein Function: | PHC1: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 12p13 Cellular Component: nucleoplasm; nuclear body; sex chromatin; PcG protein complex; nucleus Molecular Function:DNA binding; zinc ion binding; chromatin binding Biological Process: multicellular organismal development; histone ubiquitination Disease: Microcephaly 11, Primary, Autosomal Recessive |
| NCBI Summary: | This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P78364 |
| NCBI GenInfo Identifier: | 224471881 |
| NCBI Gene ID: | 1911 |
| NCBI Accession: | P78364.3 |
| UniProt Secondary Accession: | P78364,Q8WVM3, Q9BU63, D3DUV4, |
| UniProt Related Accession: | P78364 |
| Molecular Weight: | Calculated MW: 105kDaObserved MW: 125kDa/135kDa |
| NCBI Full Name: | Polyhomeotic-like protein 1 |
| NCBI Synonym Full Names: | polyhomeotic homolog 1 (Drosophila) |
| NCBI Official Symbol: | PHC1 |
| NCBI Official Synonym Symbols: | EDR1; HPH1; RAE28; MCPH11 |
| NCBI Protein Information: | polyhomeotic-like protein 1; polyhomeotic-like 1; early development regulatory protein 1; early development regulator 1 (homolog of polyhomeotic 1) |
| UniProt Protein Name: | Polyhomeotic-like protein 1 |
| UniProt Synonym Protein Names: | Early development regulatory protein 1 |
| Protein Family: | Polyhomeotic-like protein |
| UniProt Gene Name: | PHC1 |
| UniProt Entry Name: | PHC1_HUMAN |
