Description
| 抗体名: | PFKP Antibody (PACO11187) |
| 抗体コード: | PACO11187 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Human PFKP |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | phosphofructokinase, platelet;PFKP;FLJ40226;PFK-C;PFKF ; |
| UniProt Protein Function: | PFKP: phosphofructokinase, platelet type. An ubiquitous metabolic enzyme involved in the synthesis and degradation of fructose 2,6-bisphosphate. Key control step of glycolysis. An allosteric enzyme activated by ADP, AMP, or fructose bisphosphate and inhibited by ATP or citrate. Activity: ATP D-fructose 6-phosphate = ADP D-fructose 1,6-bisphosphate. The holoenzyme consists of 4 subunits. The liver and muscle enzymes are homo-tetramers of four liver or muscle isoforms, respectively. The red blood cell enzyme consists hetero-tetramers of the muscle and liver isoforms. A subunit composition with a higher proportion of platelet type subunits is found in platelets, brain and fibroblasts. |
| UniProt Protein Details: | Protein type:Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.1.11; Carbohydrate Metabolism - galactose; Kinase, other; Carbohydrate Metabolism - fructose and mannose Chromosomal Location of Human Ortholog: 10p15.3-p15.2 Cellular Component: cytosol; membrane; nucleus Molecular Function:6-phosphofructokinase activity; protein complex binding |
| NCBI Summary: | The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM; MIM 610681) and liver (PFKL; MIM 171860) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Vora (1981) [PubMed 6451249] determined that full tetrameric phophofructokinase enzyme expressed in platelets can be composed of subunits P4, P3L, and P2L2.[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q01813 |
| NCBI GenInfo Identifier: | 1346355 |
| NCBI Gene ID: | 5214 |
| NCBI Accession: | Q01813.2 |
| UniProt Secondary Accession: | Q01813,Q5VSR7, Q5VSR8, B3KS15, |
| UniProt Related Accession: | Q01813 |
| Molecular Weight: | 85596 Da |
| NCBI Full Name: | ATP-dependent 6-phosphofructokinase, platelet type |
| NCBI Synonym Full Names: | phosphofructokinase, platelet |
| NCBI Official Symbol: | PFKP |
| NCBI Official Synonym Symbols: | PFKF; PFK-C; PFK-P; ATP-PFK |
| NCBI Protein Information: | ATP-dependent 6-phosphofructokinase, platelet type |
| UniProt Protein Name: | ATP-dependent 6-phosphofructokinase, platelet type |
| UniProt Synonym Protein Names: | 6-phosphofructokinase type C; Phosphofructo-1-kinase isozyme C; PFK-C; Phosphohexokinase |
| Protein Family: | ATP-dependent 6-phosphofructokinase |
| UniProt Gene Name: | PFKP |
| UniProt Entry Name: | PFKAP_HUMAN |
![[KO Validated] PFKP Rabbit Polyclonal Antibody (CAB7916)](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/590x590/products/143885/143697/anti-pfkp-antibody-cab7916ko-validated__95713__58947.1750432079.jpg?c=1 "[KO Validated] PFKP Rabbit Polyclonal Antibody (CAB7916)")
