The PCDHB5 Polyclonal Antibody (PACO11101) offered by Assay Genie is a powerful tool for research involving PCDHB5, a cell adhesion molecule belonging to the protocadherin family. This antibody, raised in rabbits, is highly specific to human samples and is validated for use in various applications, including Western blot and immunohistochemistry.PCDHB5 is known to play a crucial role in cell-cell adhesion and communication in the nervous system, making it essential for neuronal development and function. Dysregulation of PCDHB5 has been linked to neurological disorders such as autism and schizophrenia. The PCDHB5 Polyclonal Antibody enables precise detection and analysis of PCDHB5 expression in various tissues and cell types, making it an invaluable tool for neurobiology and neurodevelopment research.
Researchers studying the roles of cell adhesion molecules in neuronal connectivity, synaptic plasticity, and neurodevelopmental disorders will find the PCDHB5 Polyclonal Antibody to be a valuable asset in their investigations. Its high specificity and sensitivity make it ideal for uncovering the intricate mechanisms underlying neuronal communication and dysfunction, paving the way for new insights and potential therapeutic targets in the field of neuroscience.
PCDHB5: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 5q31Biological Process: synaptic transmission; synaptogenesis
UniProt Protein Details:
NCBI Summary:
This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq, Jul 2008]
