Description
| 抗体名: | PAK2 Antibody |
| 抗体コード: | PACO02952 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | WB:1:500-1:2000, IHC:1:100-1:300 |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | synthesized peptide derived from human PAKgamma around the non-phosphorylation site of S192. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | PAK2; Serine/threonine-protein kinase PAK 2; Gamma-PAK; PAK65; S6/H4 kinase; p21-activated kinase 2; PAK-2; p58 |
| UniProt Protein Function: | PAK2: a protein kinase of the STE20 family. Critical effector linking RhoGTPases to cytoskeleton reorganization and nuclear signaling. Activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. |
| UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, STE; Kinase, protein; STE group; STE20 family; PAKA subfamily Chromosomal Location of Human Ortholog: 3q29 Cellular Component: cytoplasm; cytosol; nucleoplasm; perinuclear region of cytoplasm; plasma membrane Molecular Function:ATP binding; identical protein binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein tyrosine kinase activator activity; Rac GTPase binding Biological Process: actin cytoskeleton organization and biogenesis; apoptosis; axon guidance; cell migration; cell structure disassembly during apoptosis; innate immune response; negative regulation of apoptosis; negative regulation of protein kinase activity; peptidyl-serine phosphorylation; phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; programmed cell death; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of apoptosis; regulation of defense response to virus by virus; regulation of growth; regulation of MAPKKK cascade; regulation of mitotic cell cycle; Rho protein signal transduction; signal transduction; small GTPase mediated signal transduction; stimulatory C-type lectin receptor signaling pathway; stress-activated protein kinase signaling pathway; T cell costimulation; T cell receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; viral reproduction |
| NCBI Summary: | The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13177 |
| NCBI GenInfo Identifier: | 143811432 |
| NCBI Gene ID: | 5062 |
| NCBI Accession: | Q13177.3 |
| UniProt Secondary Accession: | Q13177,Q13154, Q6ISC3, |
| UniProt Related Accession: | Q13177 |
| Molecular Weight: | |
| NCBI Full Name: | Serine/threonine-protein kinase PAK 2 |
| NCBI Synonym Full Names: | p21 protein (Cdc42/Rac)-activated kinase 2 |
| NCBI Official Symbol: | PAK2 |
| NCBI Official Synonym Symbols: | PAK65; PAKgamma |
| NCBI Protein Information: | serine/threonine-protein kinase PAK 2 |
| UniProt Protein Name: | Serine/threonine-protein kinase PAK 2 |
| UniProt Synonym Protein Names: | Gamma-PAK; PAK65; S6/H4 kinase; p21-activated kinase 2; PAK-2 |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | PAK2 |
| UniProt Entry Name: | PAK2_HUMAN |
![[KO Validated] PAK2 Rabbit Polyclonal Antibody (CAB18093)](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/590x590/products/150185/149967/anti-pak2-antibody-cab18093ko-validated__52083__96394.1750435846.jpg?c=1 "[KO Validated] PAK2 Rabbit Polyclonal Antibody (CAB18093)")