The PA Polyclonal Antibody (PACO35006) is a research tool specifically designed for the study of PA, a protein involved in the regulation of immune responses. This antibody, derived from rabbit sources, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the PA protein, this antibody allows for the detection and analysis of PA in various cell types, making it an ideal tool for research in immunology and cancer studies.PA, also known as a potential immune regulator, plays a crucial role in immune function by modulating inflammation and controlling allergic responses. Its involvement in immune regulation makes it a promising target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions.
Understanding the function of PA is essential for the development of therapies that can manipulate immune responses in these disease contexts.Overall, the PACO35006 PA Polyclonal Antibody provides researchers with a valuable tool for investigating the role of PA in immune regulation and disease pathology. Its high reactivity and specificity make it a reliable option for studies aiming to better understand the immune system and develop targeted therapies for various medical conditions.
Antibody Name:
PA Antibody (PACO35006)
Antibody SKU:
PACO35006
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Influenza A virus
Immunogen:
Recombinant Influenza A virus Polymerase acid, c protein (1-716AA)
Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity. In addition of its function in viral transcription, PA also plays an essential role in viral RNA synthesis and promotes the formation of the trimeric polymerase complex.
Synonyms:
Polymerase acid, c protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2), PA
UniProt Protein Function:
Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity. In addition of its function in viral transcription, PA also plays an essential role in viral RNA synthesis and promotes the formation of the trimeric polymerase complex.
