Description
| 抗体名: | P4HA2 Antibody (PACO11043) |
| 抗体コード: | PACO11043 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Human P4HA2 |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | prolyl 4-hydroxylase, α polypeptide II; |
| UniProt Protein Function: | P4HA2: Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. Belongs to the P4HA family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Amino Acid Metabolism - arginine and proline; Oxidoreductase; EC 1.14.11.2 Chromosomal Location of Human Ortholog: 5q31 Cellular Component: intracellular membrane-bound organelle; endoplasmic reticulum lumen; endoplasmic reticulum; cytoplasm; nucleus Molecular Function:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; procollagen-proline 4-dioxygenase activity; electron carrier activity; L-ascorbic acid binding; iron ion binding Biological Process: peptidyl-proline hydroxylation to 4-hydroxy-L-proline |
| NCBI Summary: | This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O15460 |
| NCBI GenInfo Identifier: | 20455169 |
| NCBI Gene ID: | 8974 |
| NCBI Accession: | O15460.1 |
| UniProt Secondary Accession: | O15460,Q8WWN0, D3DQ85, D3DQ86, |
| UniProt Related Accession: | O15460 |
| Molecular Weight: | 535 |
| NCBI Full Name: | Prolyl 4-hydroxylase subunit alpha-2 |
| NCBI Synonym Full Names: | prolyl 4-hydroxylase, alpha polypeptide II |
| NCBI Official Symbol: | P4HA2 |
| NCBI Protein Information: | prolyl 4-hydroxylase subunit alpha-2; 4-PH alpha 2; 4-PH alpha-2; C-P4Halpha(II); collagen prolyl 4-hydroxylase alpha(II); procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II |
| UniProt Protein Name: | Prolyl 4-hydroxylase subunit alpha-2 |
| UniProt Synonym Protein Names: | Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2 |
| Protein Family: | Prolyl 4-hydroxylase |
| UniProt Gene Name: | P4HA2 |
| UniProt Entry Name: | P4HA2_HUMAN |
