Description
| 抗体名: | OPCML Antibody |
| 抗体コード: | PACO01193 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | WB:1:500-1:2000 |
| 反応性: | Human, Mouse, Rat, Monkey |
| 免疫原: | synthesized peptide derived from the Internal region of human OBCAM. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | OPCML; IGLON1; OBCAM; Opioid-binding protein/cell adhesion molecule; OBCAM; OPCML; Opioid-binding cell adhesion molecule; IgLON family member 1 |
| UniProt Protein Function: | OPCML: Binds opioids in the presence of acidic lipids; probably involved in cell contact. Defects in OPCML are a cause of susceptibility to ovarian cancer (OC). Ovarian cancer common malignancy originating from ovarian tissue. Although many histologic types of ovarian neoplasms have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late- stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. Belongs to the immunoglobulin superfamily. IgLON family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 11q25 Cellular Component: neuron projection; cell surface; cell soma; plasma membrane; intercellular junction Biological Process: cell-cell adhesion; regulation of neurogenesis; neuron recognition; cell adhesion Disease: Ovarian Cancer |
| NCBI Summary: | This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily. The encoded protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14982 |
| NCBI GenInfo Identifier: | 2497326 |
| NCBI Gene ID: | 4978 |
| NCBI Accession: | Q14982.1 |
| UniProt Secondary Accession: | Q14982,Q17RN7, Q7Z3W6, B2CZX2, B7ZLQ1, |
| UniProt Related Accession: | Q14982 |
| Molecular Weight: | 345 |
| NCBI Full Name: | Opioid-binding protein/cell adhesion molecule |
| NCBI Synonym Full Names: | opioid binding protein/cell adhesion molecule-like |
| NCBI Official Symbol: | OPCML |
| NCBI Official Synonym Symbols: | OPCM; OBCAM; IGLON1 |
| NCBI Protein Information: | opioid-binding protein/cell adhesion molecule; IgLON family member 1; opioid binding protein/cell adhesion molecule-like preprotein |
| UniProt Protein Name: | Opioid-binding protein/cell adhesion molecule |
| UniProt Synonym Protein Names: | IgLON family member 1 |
| UniProt Gene Name: | OPCML |
| UniProt Entry Name: | OPCM_HUMAN |
