| UniProt Protein Function: | NUP43: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Nucleoporin Chromosomal Location of Human Ortholog: 6q25.1 Cellular Component: cytosol; kinetochore; nuclear envelope Molecular Function:protein binding Biological Process: mitotic nuclear envelope disassembly; mRNA export from nucleus; protein sumoylation; RNA-mediated gene silencing; sister chromatid cohesion; tRNA export from nucleus; viral reproduction; viral transcription |
| NCBI Summary: | Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP43 is part of one such subcomplex, Nup107-160 (Loiodice et al., 2004 [PubMed 15146057]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q8NFH3 |
| NCBI GenInfo Identifier: | 27923819 |
| NCBI Gene ID: | 348995 |
| NCBI Accession: | Q8NFH3.1 |
| UniProt Secondary Accession: | Q8NFH3,Q9H8S0, B4E2F0, |
| UniProt Related Accession: | Q8NFH3 |
| Molecular Weight: | 31,512 Da |
| NCBI Full Name: | Nucleoporin Nup43 |
| NCBI Synonym Full Names: | nucleoporin 43 |
| NCBI Official Symbol: | NUP43 |
| NCBI Official Synonym Symbols: | p42; bA350J20.1 |
| NCBI Protein Information: | nucleoporin Nup43 |
| UniProt Protein Name: | Nucleoporin Nup43 |
| UniProt Synonym Protein Names: | Nup107-160 subcomplex subunit Nup43; p42 |
| Protein Family: | Nucleoporin |
| UniProt Gene Name: | NUP43 |
| UniProt Entry Name: | NUP43_HUMAN |
