| UniProt Protein Function: | NUDT2: Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis. Belongs to the Nudix hydrolase family. |
| UniProt Protein Details: | Protein type:Nucleotide Metabolism - pyrimidine; Apoptosis; EC 3.6.1.17; Hydrolase; Nucleotide Metabolism - purine Chromosomal Location of Human Ortholog: 9p13 Cellular Component: mitochondrial matrix Molecular Function:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity; bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity; protein binding Biological Process: apoptosis; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; response to reactive oxygen species |
| NCBI Summary: | This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified. [provided by RefSeq, Sep 2011] |
| UniProt Code: | P50583 |
| NCBI GenInfo Identifier: | 1703326 |
| NCBI Gene ID: | 318 |
| NCBI Accession: | P50583.3 |
| UniProt Secondary Accession: | P50583,Q5T589, D3DRM0, |
| UniProt Related Accession: | P50583 |
| Molecular Weight: | 16,829 Da |
| NCBI Full Name: | Bis(5'-nucleosyl)-tetraphosphatase |
| NCBI Synonym Full Names: | nudix hydrolase 2 |
| NCBI Official Symbol: | NUDT2 |
| NCBI Official Synonym Symbols: | APAH1 |
| NCBI Protein Information: | bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] |
| UniProt Protein Name: | Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] |
| UniProt Synonym Protein Names: | Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase; Ap4A hydrolase; Ap4Aase; Diadenosine tetraphosphatase; Nucleoside diphosphate-linked moiety X motif 2; Nudix motif 2 |
| Protein Family: | Nudix hydrolase |
| UniProt Gene Name: | NUDT2 |
| UniProt Entry Name: | AP4A_HUMAN |
