Description
| 抗体名: | NR2C1 Antibody (PACO10921) |
| 抗体コード: | PACO10921 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Human NR2C1 |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| 精製方法: | Antigen Affinity purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | nuclear receptor subfamily 2, group C, member 1;NR2C1;TR2 ; |
| UniProt Protein Function: | NR2C1: Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid- regulated preadipocyte proliferation. Belongs to the nuclear hormone receptor family. NR2 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding; Nuclear receptor Chromosomal Location of Human Ortholog: 12q22 Cellular Component: nucleoplasm; PML body Molecular Function:protein binding; protein homodimerization activity; DNA binding; zinc ion binding; sequence-specific DNA binding; histone deacetylase binding; steroid hormone receptor activity; receptor activity; transcription factor activity Biological Process: transcription initiation from RNA polymerase II promoter; steroid hormone mediated signaling; positive regulation of retinoic acid receptor signaling pathway; gene expression; negative regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P13056 |
| NCBI GenInfo Identifier: | 226693548 |
| NCBI Gene ID: | 7181 |
| NCBI Accession: | P13056.2 |
| UniProt Secondary Accession: | P13056,Q15625, Q15626, A8K5K4, |
| UniProt Related Accession: | P13056 |
| Molecular Weight: | 603 |
| NCBI Full Name: | Nuclear receptor subfamily 2 group C member 1 |
| NCBI Synonym Full Names: | nuclear receptor subfamily 2, group C, member 1 |
| NCBI Official Symbol: | NR2C1 |
| NCBI Official Synonym Symbols: | TR2 |
| NCBI Protein Information: | nuclear receptor subfamily 2 group C member 1; orphan nuclear receptor TR2; TR2 nuclear hormone receptor; nuclear receptor subfamily 2, group C isoform |
| UniProt Protein Name: | Nuclear receptor subfamily 2 group C member 1 |
| UniProt Synonym Protein Names: | Orphan nuclear receptor TR2; Testicular receptor 2 |
| Protein Family: | Nuclear receptor subfamily |
| UniProt Gene Name: | NR2C1 |
| UniProt Entry Name: | NR2C1_HUMAN |
