| UniProt Protein Function: | NPRL2: Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs. Belongs to the NPR2 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Tumor suppressor; Inhibitor Chromosomal Location of Human Ortholog: 3p21.3 Molecular Function:protein binding; GTPase activator activity; protein kinase activity Biological Process: negative regulation of kinase activity; protein amino acid phosphorylation; positive regulation of GTPase activity |
| UniProt Code: | Q8WTW4 |
| NCBI GenInfo Identifier: | 47117604 |
| NCBI Gene ID: | 10641 |
| NCBI Accession: | Q8WTW4.2 |
| UniProt Secondary Accession: | Q8WTW4,Q6FGS2, Q9Y249, Q9Y497, A8K831, |
| UniProt Related Accession: | Q8WTW4 |
| Molecular Weight: | Observed MW 40kDaCalculated MW 23kDa/43kDa |
| NCBI Full Name: | Nitrogen permease regulator 2-like protein |
| NCBI Synonym Full Names: | nitrogen permease regulator-like 2 (S. cerevisiae) |
| NCBI Official Symbol: | NPRL2 |
| NCBI Official Synonym Symbols: | NPR2; NPR2L; TUSC4 |
| NCBI Protein Information: | nitrogen permease regulator 2-like protein; G21 protein; 2810446G01Rik; gene 21 protein; NPR2-like protein; tumor suppressor candidate 4; homologous to yeast nitrogen permease (candidate tumor suppressor) |
| UniProt Protein Name: | Nitrogen permease regulator 2-like protein |
| UniProt Synonym Protein Names: | Gene 21 protein; G21 protein; Tumor suppressor candidate 4 |
| Protein Family: | Nitrogen permease regulator 2-like protein |
| UniProt Gene Name: | NPRL2 |
| UniProt Entry Name: | NPRL2_HUMAN |
