| UniProt Protein Function: | NOSTRIN: Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 2q31.1 Cellular Component: plasma membrane Molecular Function:protein binding Biological Process: regulation of nitric-oxide synthase activity |
| NCBI Summary: | Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.[supplied by OMIM, Apr 2004] |
| UniProt Code: | Q8IVI9 |
| NCBI GenInfo Identifier: | 317373401 |
| NCBI Gene ID: | 115677 |
| NCBI Accession: | Q8IVI9.2 |
| UniProt Secondary Accession: | Q8IVI9,Q27HG3, Q53S62, Q96CJ9, A8K2I9, B3KSF5, E7EPT9 |
| UniProt Related Accession: | Q8IVI9 |
| Molecular Weight: | 64,364 Da |
| NCBI Full Name: | Nostrin |
| NCBI Synonym Full Names: | nitric oxide synthase trafficking |
| NCBI Official Symbol: | NOSTRIN |
| NCBI Official Synonym Symbols: | DaIP2 |
| NCBI Protein Information: | nostrin |
| UniProt Protein Name: | Nostrin |
| UniProt Synonym Protein Names: | BM247 homolog; Nitric oxide synthase traffic inducer; Nitric oxide synthase trafficker; eNOS-trafficking inducer |
| Protein Family: | Nostrin |
| UniProt Gene Name: | NOSTRIN |
| UniProt Entry Name: | NOSTN_HUMAN |
