Description
| 抗体名: | NMNAT1 Antibody (PACO44401) |
| 抗体コード: | PACO44401 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC, IF |
| 推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Nicotinamide/nicotinic acid, mononucleotide adenylyltransferase 1 protein (1-279AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO44401 at dilution of 1:100. |
 | Immunofluorescent analysis of PC-3 cells using PACO44401 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| バックグラウンド: | Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid, mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid, adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following mechanical or toxic insults. |
| シノニム: | Nicotinamide/nicotinic acid, mononucleotide adenylyltransferase 1 (NMN/NaMN adenylyltransferase 1) (EC 2.7.7.1) (EC 2.7.7.18) (Nicotinamide-nucleotide adenylyltransferase 1) (NMN adenylyltransferase 1) (Nicotinate-nucleotide adenylyltransferase 1) (NaMN adenylyltransferase 1), NMNAT1, NMNAT |
| UniProt Protein Function: | NMNAT1: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following mechanical or toxic insults. Belongs to the eukaryotic NMN adenylyltransferase family. |
| UniProt Protein Details: | Protein type:EC 2.7.7.18; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Transferase; EC 2.7.7.1 Chromosomal Location of Human Ortholog: 1p36.22 Cellular Component: nucleoplasm; nucleus Molecular Function:protein binding; nicotinamide-nucleotide adenylyltransferase activity; nicotinate-nucleotide adenylyltransferase activity; ATP binding Biological Process: NAD biosynthetic process; vitamin metabolic process; NAD metabolic process; water-soluble vitamin metabolic process Disease: Leber Congenital Amaurosis 9 |
| NCBI Summary: | This gene encodes an enzyme which catalyzes a key step in the biosynthesis of nicotinamide adenine dinucleotide (NAD). The encoded enzyme is one of several nicotinamide nucleotide adenylyltransferases, and is specifically localized to the cell nucleus. Activity of this protein leads to the activation of a nuclear deacetylase that functions in the protection of damaged neurons. Mutations in this gene have been associated with Leber congenital amaurosis 9. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on chromosomes 1, 3, 4, 14, and 15. [provided by RefSeq, Jul 2014] |
| UniProt Code: | Q9HAN9 |
| NCBI GenInfo Identifier: | 30580491 |
| NCBI Gene ID: | 64802 |
| NCBI Accession: | Q9HAN9.1 |
| UniProt Secondary Accession: | Q9HAN9,Q8TAE9, Q9H247, Q9H6B6, B1AN63, |
| UniProt Related Accession: | Q9HAN9 |
| Molecular Weight: | 279 |
| NCBI Full Name: | Nicotinamide mononucleotide adenylyltransferase 1 |
| NCBI Synonym Full Names: | nicotinamide nucleotide adenylyltransferase 1 |
| NCBI Official Symbol: | NMNAT1 |
| NCBI Official Synonym Symbols: | LCA9; NMNAT; PNAT1 |
| NCBI Protein Information: | nicotinamide mononucleotide adenylyltransferase 1; NMN adenylyltransferase 1; NaMN adenylyltransferase 1; pyridine nucleotide adenylyltransferase 1; nicotinate-nucleotide adenylyltransferase 1 |
| UniProt Protein Name: | Nicotinamide mononucleotide adenylyltransferase 1 |
| UniProt Synonym Protein Names: | Nicotinate-nucleotide adenylyltransferase 1 (EC:2.7.7.18); NaMN adenylyltransferase 1 |
| UniProt Gene Name: | NMNAT1 |
| UniProt Entry Name: | NMNA1_HUMAN |
