| UniProt Protein Function: | NALP10: Inhibits CASP1/caspase-1-dependent IL1B secretion and PYCARD-mediated apoptosis, but not that induced by FAS or BID. Belongs to the NLRP family. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 11p15.4 Cellular Component: cytoplasm; extrinsic to plasma membrane Biological Process: defense response to fungus; defense response to Gram-negative bacterium; positive regulation of T-helper 1 type immune response |
| NCBI Summary: | Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q86W26 |
| NCBI GenInfo Identifier: | 46396380 |
| NCBI Gene ID: | 338322 |
| NCBI Accession: | Q86W26.1 |
| UniProt Secondary Accession: | Q86W26,Q2M3C4, Q6JGT0, |
| UniProt Related Accession: | Q86W26 |
| Molecular Weight: | 75,032 Da |
| NCBI Full Name: | NACHT, LRR and PYD domains-containing protein 10 |
| NCBI Synonym Full Names: | NLR family pyrin domain containing 10 |
| NCBI Official Symbol: | NLRP10 |
| NCBI Official Synonym Symbols: | NOD8; PAN5; PYNOD; NALP10; CLR11.1 |
| NCBI Protein Information: | NACHT, LRR and PYD domains-containing protein 10 |
| UniProt Protein Name: | NACHT, LRR and PYD domains-containing protein 10 |
| UniProt Synonym Protein Names: | Nucleotide-binding oligomerization domain protein 8 |
| Protein Family: | NACHT, LRR and PYD domains-containing protein |
| UniProt Gene Name: | NLRP10 |
| UniProt Entry Name: | NAL10_HUMAN |
