Description
| 抗体名: | NEFH Antibody (PACO10810) |
| 抗体コード: | PACO10810 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Human NEFH |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| 精製方法: | Antigen Affinity purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | neurofilament, heavy polypeptide;NEFH;NFH ; |
| UniProt Protein Function: | NFH: Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins. Belongs to the intermediate filament family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 22q12.2 Cellular Component: mitochondrion; axon; cytoplasm; neurofilament Molecular Function:protein binding, bridging; dynein binding; structural constituent of cytoskeleton; kinesin binding; microtubule binding; structural molecule activity; protein kinase binding Biological Process: axonogenesis; neurofilament bundle assembly; microtubule cytoskeleton organization and biogenesis; cell projection biogenesis; peripheral nervous system neuron axonogenesis Disease: Amyotrophic Lateral Sclerosis 1 |
| NCBI Summary: | Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq, Oct 2008] |
| UniProt Code: | P12036 |
| NCBI GenInfo Identifier: | 226726294 |
| NCBI Gene ID: | 4744 |
| NCBI Accession: | P12036.4 |
| UniProt Secondary Accession: | P12036,Q96HF8, Q9UJS7, Q9UQ14, B4DYY4, |
| UniProt Related Accession: | P12036 |
| Molecular Weight: | |
| NCBI Full Name: | Neurofilament heavy polypeptide |
| NCBI Synonym Full Names: | neurofilament, heavy polypeptide |
| NCBI Official Symbol: | NEFH |
| NCBI Official Synonym Symbols: | NFH |
| NCBI Protein Information: | neurofilament heavy polypeptide; NF-H; 200 kDa neurofilament protein; neurofilament triplet H protein; neurofilament, heavy polypeptide 200kDa |
| UniProt Protein Name: | Neurofilament heavy polypeptide |
| UniProt Synonym Protein Names: | 200 kDa neurofilament protein; Neurofilament triplet H protein |
| Protein Family: | Neurofilament heavy polypeptide |
| UniProt Gene Name: | NEFH |
| UniProt Entry Name: | NFH_HUMAN |
