Description
| 抗体名: | NDC80 Antibody |
| 抗体コード: | PACO02313 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IF |
| 推奨される希釈: | WB:1:500-1:2000, IF:1:200-1:1000 |
| 反応性: | Human, Mouse |
| 免疫原: | synthesized peptide derived from the Internal region of human Hec1. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | NDC80; HEC; HEC1; KNTC2; Kinetochore protein NDC80 homolog; Highly expressed in cancer protein; Kinetochore protein Hec1; HsHec1; Kinetochore-associated protein 2; Retinoblastoma-associated protein HEC |
| UniProt Protein Function: | HEC1: plays an essential role in chromosome segregation by interacting through its coiled-coil domains with several proteins that modulate the G2/M phase. Phosphorylation by Nek2 is essential for faithful chromosome segregation. Required for the recruitment of Mps1 kinase and Mad1/Mad2 complexes to kinetochores. |
| UniProt Protein Details: | Protein type:Cell cycle regulation Chromosomal Location of Human Ortholog: 18p11.32 Cellular Component: chromosome, pericentric region; cytosol; kinetochore; membrane; nucleus Molecular Function:identical protein binding; protein binding; structural constituent of cytoskeleton Biological Process: attachment of spindle microtubules to kinetochore; attachment of spindle microtubules to kinetochore during mitosis; chromosome segregation; establishment of mitotic spindle orientation; mitosis; mitotic sister chromatid segregation; mitotic spindle organization and biogenesis; sister chromatid cohesion |
| NCBI Summary: | This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011] |
| UniProt Code: | O14777 |
| NCBI GenInfo Identifier: | 74735330 |
| NCBI Gene ID: | 10403 |
| NCBI Accession: | O14777.1 |
| UniProt Secondary Accession: | O14777,Q6PJX2, |
| UniProt Related Accession: | O14777 |
| Molecular Weight: | 73,913 Da |
| NCBI Full Name: | Kinetochore protein NDC80 homolog |
| NCBI Synonym Full Names: | NDC80, kinetochore complex component |
| NCBI Official Symbol: | NDC80 |
| NCBI Official Synonym Symbols: | HEC; HEC1; TID3; KNTC2; HsHec1; hsNDC80 |
| NCBI Protein Information: | kinetochore protein NDC80 homolog |
| UniProt Protein Name: | Kinetochore protein NDC80 homolog |
| UniProt Synonym Protein Names: | Highly expressed in cancer protein; Kinetochore protein Hec1; HsHec1; Kinetochore-associated protein 2; Retinoblastoma-associated protein HEC |
| Protein Family: | Kinetochore protein |
| UniProt Gene Name: | NDC80 |
| UniProt Entry Name: | NDC80_HUMAN |
