Description
| 抗体名: | NANOS3 Antibody (PACO49790) |
| 抗体コード: | PACO49790 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC, IF |
| 推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Nanos homolog 3 protein (21-192AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO49790 at dilution of 1:100. |
 | Immunofluorescent analysis of Hela cells using PACO49790 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| バックグラウンド: | Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis. |
| シノニム: | Nanos homolog 3 (NOS-3), NANOS3, NOS3 |
| UniProt Protein Function: | NANOS3: Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax- dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis. Belongs to the nanos family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA-binding; Cell development/differentiation Chromosomal Location of Human Ortholog: 19p13.13 Cellular Component: perinuclear region of cytoplasm; stress granule; cytoplasm; nucleus Molecular Function:protein binding; zinc ion binding; RNA binding Biological Process: oogenesis; regulation of translation; regulation of cell cycle; multicellular organismal development; negative regulation of translation; spermatogenesis; germ cell development |
| UniProt Code: | P60323 |
| NCBI GenInfo Identifier: | 41688563 |
| NCBI Gene ID: | 342977 |
| NCBI Accession: | P60323.1 |
| UniProt Related Accession: | P60323 |
| Molecular Weight: | Observed Molecular Weight: (Observed)18kD.Predicted Molecular Weight: (Calculated)19kDa. |
| NCBI Full Name: | Nanos homolog 3 |
| NCBI Synonym Full Names: | nanos C2HC-type zinc finger 3 |
| NCBI Official Symbol: | NANOS3 |
| NCBI Official Synonym Symbols: | NOS3; NANOS1L; ZC2HC12C |
| NCBI Protein Information: | nanos homolog 3 |
| UniProt Protein Name: | Nanos homolog 3 |
| Protein Family: | Nanos |
| UniProt Gene Name: | NANOS3 |
| UniProt Entry Name: | NANO3_HUMAN |
