Description
| 抗体名: | NAA10 Antibody (PACO42948) |
| 抗体コード: | PACO42948 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human N-alpha-acetyltransferase 10 protein (161-235AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: N-alpha-acetyltransferase 10 antibody at 5µg/ml + Hela whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 27, 25 kDa. Observed band size: 27 kDa. |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO42948 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO42948 at dilution of 1:100. |
| バックグラウンド: | Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays α (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development. |
| シノニム: | N-alpha-acetyltransferase 10 (EC 2.3.1.255) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (hARD1) (NatA catalytic subunit Naa10), NAA10, ARD1 ARD1A TE2 |
| UniProt Protein Function: | NAA10: In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Interacts with HIF1A (via its ODD domain); the interaction increases HIF1A protein stability during normoxia, and down-regulates it when induced by hypoxia. Interacts with NAA15, NAA50 and with the ribosome. Binds to MYLK. Ubiquitous. Belongs to the acetyltransferase family. ARD1 subfamily. |
| UniProt Protein Details: | Protein type:Amino Acid Metabolism - tyrosine; Secondary Metabolites Metabolism - limonene and pinene degradation; Amino Acid Metabolism - phenylalanine; EC 2.3.1.88; Lipid Metabolism - glycerophospholipid; Acetyltransferase Chromosomal Location of Human Ortholog: Xq28 Cellular Component: membrane; cytoplasm; nucleolus; intracellular; nucleus Molecular Function:peptide alpha-N-acetyltransferase activity; N-acetyltransferase activity; protein binding; acetyltransferase activity; ribosome binding Biological Process: N-terminal protein amino acid acetylation; N-terminal peptidyl-glutamic acid acetylation; internal protein amino acid acetylation; N-terminal peptidyl-serine acetylation; DNA packaging Disease: Ogden Syndrome; Microphthalmia, Syndromic 1 |
| NCBI Summary: | N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes an N-terminal acetyltransferase that functions as the catalytic subunit of the major amino-terminal acetyltransferase A complex. Mutations in this gene are the cause of Ogden syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] |
| UniProt Code: | P41227 |
| NCBI GenInfo Identifier: | 728880 |
| NCBI Gene ID: | 8260 |
| NCBI Accession: | P41227.1 |
| UniProt Secondary Accession: | P41227,A6NM98, |
| UniProt Related Accession: | P41227 |
| Molecular Weight: | 235 |
| NCBI Full Name: | N-alpha-acetyltransferase 10 |
| NCBI Synonym Full Names: | N(alpha)-acetyltransferase 10, NatA catalytic subunit |
| NCBI Official Symbol: | NAA10 |
| NCBI Official Synonym Symbols: | TE2; ARD1; NATD; ARD1A; ARD1P; DXS707; MCOPS1 |
| NCBI Protein Information: | N-alpha-acetyltransferase 10; natA catalytic subunit Naa10; ARD1 homolog A, N-acetyltransferase; N-acetyltransferase ARD1, human homolog of; N-alpha-acetyltransferase 10, NatA catalytic subunit; N-terminal acetyltransferase complex ARD1 subunit homolog A |
| UniProt Protein Name: | N-alpha-acetyltransferase 10 |
| UniProt Synonym Protein Names: | N-terminal acetyltransferase complex ARD1 subunit homolog A; NatA catalytic subunit Naa10 |
| Protein Family: | N-alpha-acetyltransferase |
| UniProt Gene Name: | NAA10 |
| UniProt Entry Name: | NAA10_HUMAN |
