Description
| 抗体名: | MYO7A Antibody (PACO10703) |
| 抗体コード: | PACO10703 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IF |
| 推奨される希釈: | |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Human MYO7A |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| 精製方法: | Antigen Affinity purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | myosin VIIA;MYO7A;DFNA11;DFNB2;MYOVIIA;MYU7A;NSRD2;USH1B ; |
| UniProt Protein Function: | MYO7A: an actin-based motor molecule with ATPase activity and a calcium sensitive calmodulin binding subunit. May play a role in trafficking of ribbon- synaptic vesicle complexes and renewal of outer photoreceptor disks. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity. Seven alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Motor; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11q13.5 Cellular Component: stereocilium; photoreceptor inner segment; photoreceptor outer segment; lysosomal membrane; cytoplasm; apical plasma membrane; melanosome; synapse; cell cortex; cytosol; photoreceptor connecting cilium Molecular Function:actin filament binding; microfilament motor activity; calmodulin binding; protein domain specific binding; protein binding; protein homodimerization activity; spectrin binding; ADP binding; actin-dependent ATPase activity; ATP binding Biological Process: phagolysosome formation; intracellular protein transport; eye photoreceptor cell development; sensory perception of sound; pigment granule transport; visual perception; actin filament-based movement; lysosome organization and biogenesis; metabolic process; sensory perception of light stimulus; auditory receptor cell stereocilium organization and biogenesis; equilibrioception; post-embryonic organ morphogenesis Disease: Deafness, Autosomal Dominant 11; Deafness, Autosomal Recessive 2; Usher Syndrome, Type I |
| NCBI Summary: | This gene is a member of the myosin gene family. Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. This gene encodes an unconventional myosin with a very short tail. Defects in this gene are associated with the mouse shaker-1 phenotype and the human Usher syndrome 1B which are characterized by deafness, reduced vestibular function, and (in human) retinal degeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13402 |
| NCBI GenInfo Identifier: | 460018219 |
| NCBI Gene ID: | 4647 |
| NCBI Accession: | Q13402.2 |
| UniProt Related Accession: | Q13402 |
| Molecular Weight: | |
| NCBI Full Name: | Unconventional myosin-VIIa |
| NCBI Synonym Full Names: | myosin VIIA |
| NCBI Official Symbol: | MYO7A |
| NCBI Official Synonym Symbols: | DFNB2; MYU7A; NSRD2; USH1B; DFNA11; MYOVIIA |
| NCBI Protein Information: | unconventional myosin-VIIa |
| UniProt Protein Name: | Unconventional myosin-VIIa |
| Protein Family: | Unconventional myosin |
| UniProt Gene Name: | MYO7A |
| UniProt Entry Name: | MYO7A_HUMAN |
