| UniProt Protein Function: | MSLN: Membrane-anchored forms may play a role in cellular adhesion. Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. Belongs to the mesothelin family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor; Cell adhesion Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: Golgi apparatus; extracellular space; cell surface; membrane; plasma membrane Molecular Function:protein binding Biological Process: pancreas development; cell adhesion |
| NCBI Summary: | This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010] |
| UniProt Code: | Q13421 |
| NCBI GenInfo Identifier: | 116242654 |
| NCBI Gene ID: | 10232 |
| NCBI Accession: | Q13421.2 |
| UniProt Secondary Accession: | Q13421,Q14859, Q4VQD5, Q96GR6, Q96KJ5, Q9BR17, Q9BTR2 Q9UCB2, Q9UK57, D3DU65, |
| UniProt Related Accession: | Q13421 |
| Molecular Weight: | 67,940 Da |
| NCBI Full Name: | Mesothelin |
| NCBI Synonym Full Names: | mesothelin |
| NCBI Official Symbol: | MSLN |
| NCBI Official Synonym Symbols: | MPF; SMRP |
| NCBI Protein Information: | mesothelin; CAK1 antigen; megakaryocyte potentiating factor; soluble MPF mesothelin related protein; pre-pro-megakaryocyte-potentiating factor |
| UniProt Protein Name: | Mesothelin |
| UniProt Synonym Protein Names: | CAK1 antigen; Pre-pro-megakaryocyte-potentiating factorCleaved into the following 2 chains:Megakaryocyte-potentiating factor; MPF; Mesothelin, cleaved form |
| Protein Family: | Mesothelin |
| UniProt Gene Name: | MSLN |
| UniProt Entry Name: | MSLN_HUMAN |
