Description
| 抗体名: | MRPS16 Antibody (PACO45147) |
| 抗体コード: | PACO45147 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
| 反応性: | Human, Mouse |
| 免疫原: | Recombinant Human 28S ribosomal protein S16, mitochondrial protein (1-137AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: MRPS16 antibody at 1.35µg/ml. Lane 1: Mouse liver tissue. Lane 2: 293T whole cell lysate. Lane 3: Jurkat whole cell lysate. Lane 4: Raji whole cell lysate. Lane 5: HepG2 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 16, 14 kDa. Observed band size: 16 kDa.. |
 | Immunohistochemistry of paraffin-embedded human heart tissue using PACO45147 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO45147 at dilution of 1:100. |
| バックグラウンド: | cytoplasm, mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, structural constituent of ribosome, mitochondrial translation, mitochondrial translational elongation, mitochondrial translational termination, translation |
| シノニム: | 28S ribosomal protein S16, mitochondrial (MRP-S16) (S16mt) (Mitochondrial small ribosomal subunit protein bS16m), MRPS16, RPMS16 |
| UniProt Protein Function: | MRPS16: Defects in MRPS16 are the cause of combined oxidative phosphorylation deficiency type 2 (COXPD2). Defects in the mitochondrial oxidative phosphorylation system result in devastating, mainly multisystem, diseases. COXPD2 symptoms include fatal neonatal metabolic acidosis with agenesis of the corpus callosum. Belongs to the ribosomal protein S16P family. |
| UniProt Protein Details: | Protein type:Mitochondrial; Ribosomal; Translation Chromosomal Location of Human Ortholog: 10q22.1 Cellular Component: mitochondrion; mitochondrial small ribosomal subunit; cytoplasm; mitochondrial inner membrane Molecular Function:protein binding; structural constituent of ribosome Biological Process: translation; mitochondrial translation; organelle organization and biogenesis Disease: Combined Oxidative Phosphorylation Deficiency 2 |
| NCBI Summary: | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S16P family. The encoded protein is one of the most highly conserved ribosomal proteins between mammalian and yeast mitochondria. Three pseudogenes (located at 8q21.3, 20q13.32, 22q12-q13.1) for this gene have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y3D3 |
| NCBI GenInfo Identifier: | 7705626 |
| NCBI Gene ID: | 51021 |
| NCBI Accession: | NP_057149.1 |
| UniProt Secondary Accession: | Q9Y3D3,Q96Q60, B4E032, |
| UniProt Related Accession: | Q9Y3D3 |
| Molecular Weight: | 13,829 Da |
| NCBI Full Name: | 28S ribosomal protein S16, mitochondrial |
| NCBI Synonym Full Names: | mitochondrial ribosomal protein S16 |
| NCBI Official Symbol: | MRPS16 |
| NCBI Official Synonym Symbols: | COXPD2; RPMS16; CGI-132; MRP-S16 |
| NCBI Protein Information: | 28S ribosomal protein S16, mitochondrial |
| UniProt Protein Name: | 28S ribosomal protein S16, mitochondrial |
| Protein Family: | 28S ribosomal protein |
| UniProt Gene Name: | MRPS16 |
| UniProt Entry Name: | RT16_HUMAN |
