Description
| 抗体名: | MR1 Antibody, HRP conjugated (PACO46987) |
| 抗体コード: | PACO46987 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | Recombinant Human Major histocompatibility complex class I-related gene protein (150-253AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | HRP |
| バックグラウンド: | Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor α chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent. |
| シノニム: | Major histocompatibility complex class I-related gene protein (MHC class I-related gene protein) (Class I histocompatibility antigen-like protein), MR1 |
| UniProt Protein Function: | MR1: Has antigen presentation function. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT cells are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand- dependent. Belongs to the MHC class I family. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 1q25.3 Cellular Component: endoplasmic reticulum; plasma membrane Molecular Function:antigen binding; MHC class I receptor activity; protein binding Biological Process: antigen processing and presentation; immune response |
| NCBI Summary: | MAIT (mucosal-associated invariant T-cells) lymphocytes represent a small population of T-cells primarily found in the gut. The protein encoded by this gene is an antigen-presenting molecule that presents metabolites of microbial vitamin B to MAITs. This presentation may activate the MAITs to regulate the amounts of specific types of bacteria in the gut. Several transcript variants encoding different isoforms have been found for this gene, and a pseudogene of it has been detected about 36 kbp upstream on the same chromosome. [provided by RefSeq, Jul 2015] |
| UniProt Code: | Q95460 |
| NCBI GenInfo Identifier: | 74751679 |
| NCBI Gene ID: | 3140 |
| NCBI Accession: | Q95460.1 |
| UniProt Secondary Accession: | Q95460,O97985, O97986, Q53GM1, Q95HB8, Q9MY23, Q9NPL2 Q9TQB3, Q9TQB9, Q9TQK3, A8K2V9, B4E3B1, |
| UniProt Related Accession: | Q95460 |
| Molecular Weight: | 25,190 Da |
| NCBI Full Name: | Major histocompatibility complex class I-related gene protein |
| NCBI Synonym Full Names: | major histocompatibility complex, class I-related |
| NCBI Official Symbol: | MR1 |
| NCBI Official Synonym Symbols: | HLALS |
| NCBI Protein Information: | major histocompatibility complex class I-related gene protein |
| UniProt Protein Name: | Major histocompatibility complex class I-related gene protein |
| UniProt Synonym Protein Names: | Class I histocompatibility antigen-like protein |
| Protein Family: | Major histocompatibility complex class I-related gene protein |
| UniProt Gene Name: | MR1 |
| UniProt Entry Name: | HMR1_HUMAN |
