Description
| Product Name: | Mouse SNCA Recombinant Protein |
| Product Code: | RPPB4739 |
| Size: | 20µg |
| Species: | Mouse |
| Target: | SNCA |
| Synonyms: | Alpha-synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, NACP, PD1, PARK1, PARK4, MGC110988, ?-Synuclein, SNCA, Syn, SNCA. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The SNCA protein contains 20mM Tris-HCl buffer (pH 7.5) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGNIAA ATGFVKKDQM GKGEEGYPQE GILEDMPVDP GSEAYEMPSE EGYQDYEPEA |
a-Synuclein (amino acids 1-140), an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. a-synuclein has been suggested to be implicated in the pathogenesis of Parkinson�s disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Moreover, recent studies have shown that a-synuclein has chaperone activity and that this activity is lost upon removing its C-terminal acidic tail (amino acids 96-140).
SNCA Recombinant Mouse produced in E.Coli is a single, non-glycosylated polypeptide chain containing 140 amino acids (1-140 a.a.) and having a molecular mass of 14.4 kDa. The SNCA is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | May be involved in the regulation of dopamine release and transport. |
| UniProt Code: | O55042 |
| NCBI GenInfo Identifier: | 6678047 |
| NCBI Gene ID: | 20617 |
| NCBI Accession: | NP_033247 |
| UniProt Secondary Accession: | O55042,Q3U130, Q9CXF8, Q9EQC3, Q9QUR3, |
| UniProt Related Accession: | O55042 |
| Molecular Weight: | 14.4 kDa (140aa), confirmed by MALDI-TOF |
| NCBI Full Name: | alpha-synuclein |
| NCBI Synonym Full Names: | synuclein, alpha |
| NCBI Official Symbol: | Snca�� |
| NCBI Official Synonym Symbols: | NACP; alphaSYN; alpha-Syn�� |
| NCBI Protein Information: | alpha-synuclein |
| UniProt Protein Name: | Alpha-synuclein |
| UniProt Synonym Protein Names: | Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP |
| Protein Family: | Alpha-synuclein |
| UniProt Gene Name: | Snca�� |
