Description
| Product Name: | Mouse NUCB2 Recombinant Protein |
| Product Code: | RPPB4137 |
| Size: | 25µg |
| Species: | Mouse |
| Target: | NUCB2 |
| Synonyms: | Nefa, Calnuc, AI607786, Nucleobindin-2, DNA-binding protein NEFA, Nucb2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The protein solution (1mg/ml) contains 20mM Tris-HCl pH-8, 0.1M NaCl and 1mM EDTA. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MVPIDVDKTK VHNTEPVENA RIEPPDTGLY YDEYLKQVIE VLETDPHFRE KLQKADIEEI RSGRLSQELD LVSHKVRTRL DELKRQEVGR LRMLIKAKLD ALQDTGMNHH LLLKQFEHLN HQNPNTFESR DLDMLIKAAT ADLEQYDRTR HEEFKKYEMMKEHERREYLK TLSEEKRKEE ESKFEEMKRK HEDHPKVNHP GSKDQLKEVW EETDGLDPND FDPKTFFKLH DVNNDGFLDE QELEALFTRE LEKVYNPQNA EDDMIEMEEE RLRMREHVMS EIDNNKDRLV TLEEFLRATE KKEFLEPDSW ETLDQQQLFT EDELKEYESI IAIQENELKKRAEELQKQKE DLQRQHDHLE AQKQEYHQAV QHLEQKKLQQ GIAPSGPAGE LKFEPHT |
Nucleobindin-2 (NUCB2) is a EF-hand calcium-binding protein. Nucleobindin-2 takes part in calcium homeostasis and is a multifunctional protein that interacts with Ca(2+) nucleic acids & various regulatory proteins in different signaling pathways. NUCB2 is localized in neuronal perikarya and dendrites of mouse brain.
NUCB2 Mouse Recombinant fused to N-terminal His-Tag produced in E.Coli is a single, non-glycosylated polypeptide chain (amino acids 25-420) containing 417 amino acids and having a molecular mass of 49kDa.NUCB2 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | NUCB2: Calcium-binding protein. May have a role in calcium homeostasis. Belongs to the nucleobindin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Vesicle Chromosomal Location of Human Ortholog: 7|7 F1 Cellular Component: cytoplasm; endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; extracellular region; extracellular space; Golgi apparatus; Golgi medial cisterna; membrane; nuclear outer membrane; nucleus Molecular Function:calcium ion binding; DNA binding; metal ion binding; tumor necrosis factor receptor binding Biological Process: cellular calcium ion homeostasis; negative regulation of appetite; negative regulation of cAMP biosynthetic process; negative regulation of fat cell differentiation; negative regulation of insulin receptor signaling pathway; positive regulation of fatty acid oxidation |
| UniProt Code: | P81117 |
| NCBI GenInfo Identifier: | 194440700 |
| NCBI Gene ID: | 53322 |
| NCBI Accession: | NP_001123951.1 |
| UniProt Related Accession: | P81117 |
| Molecular Weight: | 50,304 Da |
| NCBI Full Name: | nucleobindin-2 |
| NCBI Synonym Full Names: | nucleobindin 2 |
| NCBI Official Symbol: | Nucb2�� |
| NCBI Official Synonym Symbols: | Nefa; Calnuc; AI607786; Nesfatin-1�� |
| NCBI Protein Information: | nucleobindin-2 |
| UniProt Protein Name: | Nucleobindin-2 |
| UniProt Synonym Protein Names: | DNA-binding protein NEFA; Prepronesfatin |
| UniProt Gene Name: | Nucb2�� |
