Description
| Product Name: | Mouse NTRK2 Recombinant Protein |
| Product Code: | RPPB0812 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | NTRK2 |
| Synonyms: | TrkB, NTRK2, NTRK-2,�Tyrosine Kinase Receptor B,�BDNF/NT-3 Growth Factors Receptor |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterilefiltered colorless solution. |
| Formulation: | NTRK2 Mouse protein solution (0.5mg/ml) contains PBS pH 7.4 and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | CPTSCKCSSARIWCTEPSPG IVAFPRLEPN SVDPENITEI LIANQKRLEI INEDDVEAYV GLRNLTIVDS GLKFVAYKAFLKNSNLRHIN FTRNKLTSLS RRHFRHLDLS DLILTGNPFT CSCDIMWLKT LQETKSSPDT QDLYCLNESSKNMPLANLQI PNCGLPSARL AAPNLTVEEG KSVTLSCSVG GDPLPTLYWD VGNLVSKHMN ETSHTQGSLRITNISSDDSG KQISCVAENL VGEDQDSVNL TVHFAPTITF LESPTSDHHW CIPFTVRGNP KPALQWFYNGAILNESKYIC TKIHVTNHTE YHGCLQLDNP THMNNGDYTL MAKNEYGKDE RQISAHFMGR PGVDYETNPNYPEVLYEDWT TPTDIGDTTN KSNEIPSTDV ADQSNREHAA ALEHHHHHH |
NTRK2 plays a role in the growth and the development of the central and the peripheral nervous systems using the regulation of neuron proliferation, migration, survival, differentiation, and synapse production. NTRK2 is a receptor for B-DNF and NT4. NTRK2 binds to neurotrophin-3 which regulates neuron survival through NTRK2. NTRK-2 activates numerous effectors such as SHC-1, SH2B-1, PLCG-1 and SH2B-2 that control overlapping signaling cascades.
NTRK2 Mouse produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 409 amino acids (32-429a.a.) and having a molecular mass of 45.7kDa (Molecular size on SDS-PAGE will appear at approximately 57-70kDa under reducing conditions).NTRK2 Mouse is expressed with an 11 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TrkB: a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). Involved in the development and maintenance of the nervous system. Three splice variant isoforms have been described. |
| UniProt Protein Details: | Protein type:Protein kinase, tyrosine (receptor); EC 2.7.10.1; Membrane protein, integral; Kinase, protein; Protein kinase, TK; TK group; Trk family Cellular Component: cell surface; rough endoplasmic reticulum; integral to plasma membrane; cell; postsynaptic density; dendrite; integral to membrane; dendritic spine; excitatory synapse; terminal button; perikaryon; cytosol; postsynaptic membrane; growth cone; membrane; cell soma; axon; cytoplasm; presynaptic active zone; plasma membrane; intracellular; nerve terminal; receptor complex; endosome Molecular Function:neurotrophin binding; protein homodimerization activity; ephrin receptor binding; nucleotide binding; transmembrane receptor protein tyrosine kinase activity; neurotrophin receptor activity; protein kinase activity; transferase activity; brain-derived neurotrophic factor receptor activity; protein binding; brain-derived neurotrophic factor binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; kinase activity; ATP binding Biological Process: mechanoreceptor differentiation; retinal rod cell development; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; multicellular organismal development; regulation of neurotransmitter secretion; regulation of dendrite development; neuron migration; protein amino acid phosphorylation; positive regulation of synaptic transmission, glutamatergic; neuron differentiation; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; oligodendrocyte differentiation; feeding behavior; negative regulation of neuron apoptosis; regulation of metabolic process; vasculogenesis; cell differentiation; neuromuscular junction development; central nervous system neuron development; nervous system development; regulation of GTPase activity; brain-derived neurotrophic factor receptor signaling pathway; regulation of protein kinase B signaling cascade; learning; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; peripheral nervous system neuron development; glutamate secretion; long-term memory; regulation of MAPKKK cascade; positive regulation of axonogenesis; cerebral cortex development; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway |
| UniProt Code: | P15209 |
| NCBI GenInfo Identifier: | 136237 |
| NCBI Gene ID: | 18212 |
| NCBI Accession: | P15209.1 |
| UniProt Secondary Accession: | P15209,Q3TUF9, Q80WU0, Q91XJ9, |
| UniProt Related Accession: | P15209 |
| Molecular Weight: | 83,744 Da |
| NCBI Full Name: | BDNF/NT-3 growth factors receptor |
| NCBI Synonym Full Names: | neurotrophic tyrosine kinase, receptor, type 2 |
| NCBI Official Symbol: | Ntrk2�� |
| NCBI Official Synonym Symbols: | Tkrb; trkB; trk-B; GP145-TrkB/GP95-TrkB�� |
| NCBI Protein Information: | BDNF/NT-3 growth factors receptor; trkB tyrosine kinase; neurotrophic tyrosine receptor kinase type 2 |
| UniProt Protein Name: | BDNF/NT-3 growth factors receptor |
| UniProt Synonym Protein Names: | GP145-TrkB/GP95-TrkB; Trk-B; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase |
| Protein Family: | BDNF/NT-3 growth factors receptor |
| UniProt Gene Name: | Ntrk2�� |
| UniProt Entry Name: | NTRK2_MOUSE |
