Description
| Product Name: | Mouse LAIR1 Recombinant Protein |
| Product Code: | RPPB3834 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | LAIR1 |
| Synonyms: | Leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, mLAIR1, CD305, LAIR1. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | LAIR1 protein solution (0.5mg/ml) contains Phosphate buffered saline (pH7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPQEGSLPD ITIFPNSSLM ISQGTFVTVV CSYSDKHDLY NMVRLEKDGS TFMEKSTEPY KTEDEFEIGP VNETITGHYS CIYSKGITWS ERSKTLELKV IKENVIQTPA PGPTSDTSWL KTYSIYHHHH HH |
LAIR1 is a glycoprotein expressed on the surface of the majority of human peripheral blood mononuclear leukocytes including T cells, B cells, NK cells, macrophages and dendritic cells. LAIR-1 functions as an inhibitory receptor in NK cells, T cells and B cells. Inhibitory receptors control the immune response to prevent lysis of cells recognized as self. Lair1 consists of a leader sequence, extracellular domain, transmembrane domain, cytoplasmic region.LAIR1 is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. LAIR1 maps to a region of 19q13.4 labeled the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.
LAIR1 Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 132 amino acids (22-144 aa) and having a molecular mass of 15kDa (Migrates at 18-28kDa on SDS-PAGE under reducing conditions).LAIR1 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | LAIR-1: an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region called the leukocyte receptor cluster, which contains at least 25 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.Protein type: Membrane protein, integral; Receptor, misc.Chromosomal Location of Human Ortholog: 7 A1|7 2.31 cMCellular Component: plasma membrane |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8BG84 |
| NCBI GenInfo Identifier: | 164698422 |
| NCBI Gene ID: | 52855 |
| NCBI Accession: | NP_001106945.1 |
| UniProt Secondary Accession: | Q8BG84,Q80UN5, Q8BHB6, Q8BRR6, Q8C6N8, Q8CEP5 |
| UniProt Related Accession: | Q8BG84 |
| Molecular Weight: | 25,128 Da |
| NCBI Full Name: | leukocyte-associated immunoglobulin-like receptor 1 isoform a |
| NCBI Synonym Full Names: | leukocyte-associated Ig-like receptor 1 |
| NCBI Official Symbol: | Lair1�� |
| NCBI Official Synonym Symbols: | Lair-1; BB115266; D7Bwg0421e; 5133400O11Rik�� |
| NCBI Protein Information: | leukocyte-associated immunoglobulin-like receptor 1 |
| UniProt Protein Name: | Leukocyte-associated immunoglobulin-like receptor 1 |
| UniProt Synonym Protein Names: | CD_antigen: CD305 |
| Protein Family: | Leukocyte-associated immunoglobulin-like receptor |
| UniProt Gene Name: | Lair1�� |
| UniProt Entry Name: |
