Description
| Product Name: | Mouse IL-22 Antagonist Recombinant Protein |
| Product Code: | RPPB0642 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | IL-22 Antagonist |
| Synonyms: | IL-TIF, TIFa, IL-10-related T-cell-derived-inducible factor, IL-22, ILTIF, IL-D110, zcyto18, MGC79382, MGC79384, TIFIL-23. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | IL-22�Antagonist Mouse�is lyophilized from a concentrated (1mg/ml) solution in water containing NaHCO3. |
| Solubility: | It is recommended to reconstitute the lyophilized Interleukin -22 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Interleukin-22 Mouse Antagonist�although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL22�Antagonist�should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles. |
| Purity: | Greater than 98.0% as determined by:(a) Gel filtration chromatography under non-denaturing conditions.(b) Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel. |
| Amino Acid Sequence: | The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Leu-Pro-Val-Asn |
| Biological Activity: | IL-22 E117A mutant is capable of full inhibition of STAT3 phosphorylation induced by mouse interleukin 22 in HepG cells. Its affinity toward immobilized mIL-22 receptor a1 extracellular domain (mIL-22 Ra1-ECD) or IL-22 binding protein is similar to the non-mutated mouse interleukin 22. Mouse IL-22 antagonist (E117A) has very low agonistic activity in this bioassay. |
IL-22 is a member of the IL-10 family of regulatory cytokines.Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-beta/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family.
Interleukin-22 Antagonist Mouse Recombinant produced in E.Coli is a single, non-glycosylated homodimeric polypeptide chain containing 147 amino acids and having a total molecular mass of 16.7 KDa. The Mouse IL-22 Antagonist is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL22: Cytokine that contributes to the inflammatory response in vivo. Belongs to the IL-10 family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Cytokine; Secreted Cellular Component: extracellular space; extracellular region Molecular Function:protein binding; cytokine activity Biological Process: regulation of tyrosine phosphorylation of Stat3 protein; negative regulation of inflammatory response; positive regulation of transcription from RNA polymerase II promoter |
| UniProt Code: | Q9JJY9 |
| NCBI GenInfo Identifier: | 17366895 |
| NCBI Gene ID: | 50929 |
| NCBI Accession: | Q9JJY9.1 |
| UniProt Secondary Accession: | Q9JJY9,Q14BB3, |
| UniProt Related Accession: | Q9JJY9 |
| Molecular Weight: | 20,106 Da |
| NCBI Full Name: | Interleukin-22 |
| NCBI Synonym Full Names: | interleukin 22 |
| NCBI Official Symbol: | Il22�� |
| NCBI Official Synonym Symbols: | IL-22; Iltif; IL-22a; ILTIFa�� |
| NCBI Protein Information: | interleukin-22; ILTIF alpha; IL-TIF alpha; interleukin-22a; IL-10-related T-cell-derived-inducible factor; interleukin 10-related T cell-derived inducible factor |
| UniProt Protein Name: | Interleukin-22 |
| UniProt Synonym Protein Names: | IL-10-related T-cell-derived-inducible factor; IL-TIF; IL-TIF alpha; Interleukin-22a; IL-22a |
| UniProt Gene Name: | Il22�� |
| UniProt Entry Name: | IL22_MOUSE |
