Description
| Product Name: | Mouse IL 16 Recombinant Protein |
| Product Code: | RPPB0594 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | IL 16 |
| Synonyms: | LCF, Lymphocyte Chemoattractant Factor, prIL-16, KIAA4048, mKIAA4048, Il16, IL-16, Interleukin-16. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Murine IL-16 was lyophilized from 1mg/ml solution after extensive dialysis against 10mM sodium phosphate buffer, pH-7.5. |
| Solubility: | It is recommended to reconstitute the lyophilized Murine IL16 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Mouse IL-16 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution mouse IL16 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis SDS-PAGE. |
| Amino Acid Sequence: | MHDLNSSTDS AASASAASDI SVESKEATVC TVTLEKTSAG LGFSLEGGKG SLHGDKPLTI NRIFKGDRTG EMVQPGDEIL QLAGTAVQGL TRFEAWNVIK ALPDGPVTIV IRRTSLQCKQ TTASADS |
IL-16 is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of IL-16 is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. IL-16 functions exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Two transcript variants encoding different isoforms have been found for this gene.IL-16 stimulates a migratory response in cd4+ lymphocytes, monocytes, and eosinophils. Also induces t-lymphocyte expression of interleukin 2 receptor. ligand for cd4.
Interleukin-16 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 127 amino acids and having a molecular mass of 13.2 kDa. The Mouse IL-16 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL16: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. 3 isoforms of the human protein are produced by alternative promoter. |
| UniProt Protein Details: | Protein type:Cytokine; DNA-binding; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 7 D3|7 47.43 cM Cellular Component: cytoplasm; intracellular; nucleus; plasma membrane Molecular Function:cytokine activity; protein binding Biological Process: induction of positive chemotaxis; leukocyte chemotaxis |
| UniProt Code: | O54824 |
| NCBI GenInfo Identifier: | 52138550 |
| NCBI Gene ID: | 16170 |
| NCBI Accession: | NP_034681.2 |
| UniProt Secondary Accession: | O54824,O70236, Q3TEM4, Q5DTR5, Q8R0G5, Q9QZP6, |
| UniProt Related Accession: | O54824 |
| Molecular Weight: | 66,471 Da |
| NCBI Full Name: | pro-interleukin-16 |
| NCBI Synonym Full Names: | interleukin 16 |
| NCBI Official Symbol: | Il16�� |
| NCBI Official Synonym Symbols: | mKIAA4048�� |
| NCBI Protein Information: | pro-interleukin-16 |
| UniProt Protein Name: | Pro-interleukin-16 |
| UniProt Synonym Protein Names: | Interleukin-16; IL-16 |
| Protein Family: | Pro-interleukin |
| UniProt Gene Name: | Il16�� |
