Description
| Product Name: | Mouse IGFBP6 Recombinant Protein |
| Product Code: | RPPB0438 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | IGFBP6 |
| Synonyms: | Insulin-like growth factor-binding protein 6, Igfbp6, IGFBP-6, IBP-6, IGF-binding protein 6, IGFBP-6, Igfbp-6. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | IGFBP6 protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 40% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ALAGCPGCGA GMQTGCRGGC VEEEDAGSPA DGCTEAGGCL RREGQPCGVY SPKCAPGLQC QPRENEEAPL RALLIGQGRC QRARGPSEET TKESKPQGGA SRSRDTNHRD RQKNPRTSAA PIRPNPVQDS EMGPCRRHLD SVLQQLQTEV FRGGARGLYV PNCDLRGFYR KQQCRSSQGN RRGPCWCVDP MGQPLPVSPD GQGSTQCSAR SSGLEHHHHH H |
IGFBP6 plays a role in lipoprotein assembly and dietary cholesterol absorption. in addition to its acyltransferase activity, it may act as a ligase. may provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.
IGFBP6 Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 221 amino acids (26-238 a.a.) and having a molecular mass of 23.7kDa (Migrates at 28-40kDa on SDS-PAGE under reducing conditions).IGFBP6 is expressed with a 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IGFBP6: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 12q13 Cellular Component: Golgi apparatus; extracellular space; extracellular region Molecular Function:insulin-like growth factor I binding; insulin-like growth factor II binding Biological Process: negative regulation of cell proliferation; cellular protein metabolic process; regulation of insulin-like growth factor receptor signaling pathway; regulation of cell growth; signal transduction |
| UniProt Code: | P47880 |
| NCBI GenInfo Identifier: | 11321593 |
| NCBI Gene ID: | 3489 |
| NCBI Accession: | NP_002169.1 |
| UniProt Secondary Accession: | P47880,P47880, |
| UniProt Related Accession: | P24592 |
| Molecular Weight: | 25,322 Da |
| NCBI Full Name: | insulin-like growth factor-binding protein 6 |
| NCBI Synonym Full Names: | insulin-like growth factor binding protein 6 |
| NCBI Official Symbol: | IGFBP6�� |
| NCBI Official Synonym Symbols: | IBP6�� |
| NCBI Protein Information: | insulin-like growth factor-binding protein 6; IBP-6; IGFBP-6; IGF binding protein 6; IGF-binding protein 6 |
| UniProt Protein Name: | Insulin-like growth factor-binding protein 6 |
| Protein Family: | Insulin-like growth factor-binding protein |
| UniProt Gene Name: | IGFBP6�� |
| UniProt Entry Name: | IBP6_HUMAN |
