Description
| Product Name: | Mouse FCGRT Recombinant Protein |
| Product Code: | RPPB3529 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | FCGRT |
| Synonyms: | IgG receptor FcRn large subunit p51, FcRn, IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor, Fcgrt, Fcrn. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | FCGRT protein solution (0.5mg/ml) contains Phosphate buffered saline (pH7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPSETRPPL MYHLTAVSNP STGLPSFWAT GWLGPQQYLT YNSLRQEADP CGAWMWENQV SWYWEKETTD LKSKEQLFLE ALKTLEKILN GTYTLQGLLG CELASDNSSV PTAVFALNGE EFMKFNPRIG NWTGEWPETE IVANLWMKQP DAARKESEFL LNSCPERLLG HLERGRRNLE WKEPPSMRLK ARPGNSGSSV LTCAAFSFYP PELKFRFLRN GLASGSGNCS TGPNGDGSFH AWSLLEVKRG DEHHYQCQVE HEGLAQPLTV DLDSSARSSH HHHHH |
Fc Fragment Of IgG Receptor AndTransporter also known as FCGRT is a transmembrane glycoprotein with structuralhomology to MHC class 1 proteins. FCGRT is widely expressed in endothelial andepithelial cells and takes a vital part in IgG homeostasis. Moreover, FCGRT is expressedin neutrophils in addition myeloid antigen presenting cells. FCGRT can enhanceIgG-meditated phagocytosis as well as antigen presentation by heses cells, howeverit promotes the degradation of opsonizing IgG rather than returning it to thecirculation.
FCGRT Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 285 amino acids (22-297 a.a) and having a molecular mass of 32.1kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).FCGRT is fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | FCGRT: Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus. Belongs to the immunoglobulin superfamily.Protein type: Immunoglobulin superfamily; Receptor, misc.; Membrane protein, integralCellular Component: membrane; integral to membrane; plasma membraneMolecular Function: IgG binding; beta-2-microglobulin binding; IgG receptor activity; antigen bindingBiological Process: antigen processing and presentation; immune response |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q61559 |
| NCBI GenInfo Identifier: | 170172528 |
| NCBI Gene ID: | 14132 |
| NCBI Accession: | NP_034319.2 |
| UniProt Secondary Accession: | Q61559,Q9QUR0, Q9R2A5 |
| UniProt Related Accession: | Q61559 |
| Molecular Weight: | 40,093 Da |
| NCBI Full Name: | IgG receptor FcRn large subunit p51 |
| NCBI Synonym Full Names: | Fc receptor, IgG, alpha chain transporter |
| NCBI Official Symbol: | Fcgrt�� |
| NCBI Official Synonym Symbols: | FcRn�� |
| NCBI Protein Information: | IgG receptor FcRn large subunit p51; neonatal Fc receptor; igG Fc fragment receptor transporter alpha chain |
| UniProt Protein Name: | IgG receptor FcRn large subunit p51 |
| UniProt Synonym Protein Names: | IgG Fc fragment receptor transporter alpha chain; Neonatal Fc receptor |
| Protein Family: | |
| UniProt Gene Name: | Fcgrt�� |
| UniProt Entry Name: | FCGRN_MOUSE |
