Description
| Product Name: | Mouse DLL4 Recombinant Protein |
| Product Code: | RPPB3362 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | DLL4 |
| Synonyms: | Delta-like protein 4, Drosophila Delta homolog 4, Delta 4, Dll4. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | DLL4 protein solution (1mg/ml) contains Phosphate buffered saline (pH7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | GSGIFQLRLQ EFVNQRGMLA NGQSCEPGCR TFFRICLKHF QATFSEGPCT FGNVSTPVLG TNSFVVRDKN SGSGRNPLQL PFNFTWPGTF SLNIQAWHTP GDDLRPETSP GNSLISQIII QGSLAVGKIW RTDEQNDTLT RLSYSYRVIC SDNYYGESCS RLCKKRDDHF GHYECQPDGS LSCLPGWTGK YCDQPICLSG CHEQNGYCSK PDECICRPGW QGRLCNECIP HNGCRHGTCS IPWQCACDEG WGGLFCDQDL NYCTHHSPCK NGSTCSNSGP KGYTCTCLPG YTGEHCELGL SKCASNPCRN GGSCKDQENS YHCLCPPGYY GQHCEHSTLT CADSPCFNGG SCRERNQGSS YACECPPNFT GSNCEKKVDR CTSNPCANGG QCQNRGPSRT CRCRPGFTGT HCELHISDCA RSPCAHGGTC HDLENGPVCT CPAGFSGRRC EVRITHDACA SGPCFNGATC YTGLSPNNFV CNCPYGFVGS RCEFPVGLPP SFPWVAHHHH HH |
Delta-Like4, also known as DLL4is implicated in the Notch signaling pathway as Notch ligand. Consequently DLL4negatively regulates endothelial cell proliferation, migration as well asangiogenic sprouting. DLL4 is vital for retinal progenitor proliferation andalso required for suppressing rod fates in late retinal progenitors and forproper generation of other retinal cell types. Furthermore, at some stage inthe spinal cord neurogenesis, DLL4 inhibits V2a interneuron fate.
DLL4 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (27-532 a.a.) and fused to a 6 aa His Tag at C-terminus containing a total of 512 amino acids and having a molecular mass of 55.8kDa.DLL4 shows multiple bands between 50-70kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | DLL4: Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4. Binds to Notch-1 and Notch-4. Expressed in vascular endothelium.Protein type: Cell development/differentiation; Membrane protein, integralCellular Component: membrane; integral to plasma membrane; integral to membraneMolecular Function: protein binding; calcium ion binding; Notch bindingBiological Process: nervous system development; Notch signaling pathway; multicellular organismal development; response to stimulus; negative regulation of transcription from RNA polymerase II promoter; negative regulation of blood vessel endothelial cell migration; patterning of blood vessels; negative regulation of cell proliferation; regulation of neurogenesis; visual perception; blood vessel remodeling; cell communication; angiogenesis; cell differentiation |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9JI71 |
| NCBI GenInfo Identifier: | 341940447 |
| NCBI Gene ID: | 54485 |
| NCBI Accession: | Q9JI71.2 |
| UniProt Secondary Accession: | Q9JI71,Q9DBU9, Q9JHZ7 |
| UniProt Related Accession: | Q9JI71 |
| Molecular Weight: | 74,991 Da |
| NCBI Full Name: | Delta-like protein 4 |
| NCBI Synonym Full Names: | delta-like 4 (Drosophila) |
| NCBI Official Symbol: | Dll4�� |
| NCBI Official Synonym Symbols: | Delta4�� |
| NCBI Protein Information: | delta-like protein 4; drosophila Delta homolog 4 |
| UniProt Protein Name: | Delta-like protein 4 |
| UniProt Synonym Protein Names: | Drosophila Delta homolog 4; Delta4 |
| Protein Family: | Delta-like protein |
| UniProt Gene Name: | Dll4�� |
| UniProt Entry Name: | DLL4_MOUSE |
