Description
| Product Name: | Mouse C-10 Recombinant Protein |
| Product Code: | RPPB1106 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | C-10 |
| Synonyms: | Small inducible cytokine A6, CCL6, C10 protein, c10, MRP-1, Scya6, chemokine (C-C motif) ligand 6. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | CCL6 Mouse was lyophilized from a 0.2�m filtered concentrated solution in 1�PBS, pH 7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized C10 protein in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized C10 protein although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL6 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | GLIQEIEKED RRYNPPIIHQ GFQDTSSDCC FSYATQIPCK RFIYYFPTSG GCIKPGIIFI SRRGTQVCAD PSDRRVQRCL STLKQGPRSG NKVIA |
| Biological Activity: | The Biological activity was determined by its ability to chemoattract human CCR1 transfected BaF3 mouse proB cells using a concentration range of 0.05-0.25�g/ml. |
Chemokine (C-C motif) ligand 6 (CCL6) is a small cytokine belonging to the CC chemokine family that has only been identified in rodents.In mice, CCL6 is expressed in cells from neutrophil and macrophage lineages, and can be greatly induced under conditions suitable for myeloid cell differentiation. It is highly expressed in bone marrow cultures that have been stimulated with the cytokine GM-CSF. Some low levels of gene expression also occur in certain cell lines of myeloid origin (e.g. the immature myeloid cell lines DA3 and 32D cl3, and the macrophage cell line P388D) that can also be greatly induced in culture with GM-CSF. However, in activated T cell lines, expression of CCL6 is greatly reduced. CCL6 can also be induced in the mouse lung by the cytokine interleukin 13. Mouse CCL6 is located on chromosome 11. The cell surface receptor for CCL6 is believed to be the chemokine receptor CCR1.
C-10 Mouse Recombinant produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 95 amino acids and having a molecular mass of 10.7kDa.The CCL6 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CCL6: Shows chemotactic activity for monocytes, resting T- lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23. Belongs to the intercrine beta (chemokine CC) family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide Cellular Component: extracellular space; extracellular region Molecular Function:chemokine activity; cytokine activity Biological Process: immune response; chemotaxis |
| UniProt Code: | P27784 |
| NCBI GenInfo Identifier: | 115197 |
| NCBI Gene ID: | 20305 |
| NCBI Accession: | P27784.1 |
| UniProt Secondary Accession: | P27784,Q3U3W3, Q5QNW1, Q99M24, Q9D830, |
| UniProt Related Accession: | P27784 |
| Molecular Weight: | 12,984 Da |
| NCBI Full Name: | C-C motif chemokine 6 |
| NCBI Synonym Full Names: | chemokine (C-C motif) ligand 6 |
| NCBI Official Symbol: | Ccl6�� |
| NCBI Official Synonym Symbols: | c10; MRP-1; Scya6�� |
| NCBI Protein Information: | C-C motif chemokine 6; CC chemokine C10; small inducible cytokine A6; small-inducible cytokine A6 |
| UniProt Protein Name: | C-C motif chemokine 6 |
| UniProt Synonym Protein Names: | Protein C10; Small-inducible cytokine A6Cleaved into the following 2 chains:CCL6(22-95); CCL6(23-95) |
| Protein Family: | Para-Rep |
| UniProt Gene Name: | Ccl6�� |
| UniProt Entry Name: | CCL6_MOUSE |
