The MORC1 Polyclonal Antibody (PACO46750) is a valuable tool for researchers studying the MORC1 protein, a member of the microrchidia (MORC) family involved in epigenetic regulation and chromatin remodeling. This antibody, produced in rabbits, shows high specificity for human samples and has been validated for use in Western blot applications.MORC1 has been linked to various cellular processes, including transcriptional regulation and DNA repair, making it a promising target for investigations in the fields of genetics and cancer biology.
By detecting and analyzing MORC1 expression in different cell types, researchers can gain insights into its role in normal physiology and disease states.Furthermore, understanding the function of MORC1 may provide valuable information for developing targeted therapies for conditions such as cancer, where dysregulation of epigenetic mechanisms can contribute to tumor progression. The MORC1 Polyclonal Antibody offers a reliable tool for researchers seeking to explore the complexities of MORC1 biology and its implications for human health.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO46750 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO46750 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human cervical cancer using PACO46750 at dilution of 1:100.
Background:
Required for spermatogenesis.
Synonyms:
MORC family CW-type zinc finger protein 1 (Cancer/testis antigen 33) (CT33), MORC1, MORC
UniProt Protein Function:
MORC1: Required for spermatogenesis.Protein type: Oxidoreductase; Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: 3q13
UniProt Protein Details:
NCBI Summary:
This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting entry into apoptosis because testis from knockout mice show greatly increased numbers of apoptotic cells. [provided by RefSeq, Jan 2009]
