Description
| Product Name: | Monkey GCSF Recombinant Protein |
| Product Code: | RPPB0323 |
| Size: | 10µg |
| Species: | Monkey |
| Target: | GCSF |
| Synonyms: | CSF3, MGI-1G, GM-CSF beta, Pluripoietin, G-CSF, GCSF. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a 0.2?m filtered concentrated solution in PBS, pH7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized Granulocyte Colony Stimulating Rhesus Macaque in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized GCSF although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Granulocyte Colony Stimulating Rhesus Macaque should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles. |
| Purity: | Greater than 98.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | TPLGPASSLP QSFLLKCLEQ VRKIQGDGAA LQEKLCATYK LCHPEELVLL RHSLGIPWAP LSSCPSQALQ LTGCLSQLHS SLFLYQGLLQ ALEGISPELS PTLDTLQLDI ADFATTIWQQ MEDLGMAPAL QPTQGAMPAF TSAFQRRAGG VLVASHLQRF LELAYRVLRH LAQS |
| Biological Activity: | The ED50 as determined by a cell proliferation assay using murine NFS-60 cells is < ��0.05 ng/ml, corresponding to a specific activity of > 2.0 � 107 IU/mg. |
GCSF is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. 3 transcript variants encoding 3 different isoforms have been found for the GCSF�gene. Granulocyte/macrophage colony-stimulating factors are cytokines that take part in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This csf induces granulocytes.
Granulocyte Colony Stimulating Rhesus Macaque Recombinant produced in E.Coli is a non-glycosylated polypeptide chain containing 174 amino acids and having a molecular mass of approximately 18.9kDa.GCSF is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | G-CSF: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytokine; Secreted, signal peptide; Cell cycle regulation; Secreted Chromosomal Location of Human Ortholog: 17q11.2-q12 Cellular Component: extracellular space Molecular Function:enzyme binding; growth factor activity; cytokine activity; granulocyte colony-stimulating factor receptor binding Biological Process: positive regulation of protein binding; positive regulation of myeloid cell differentiation; granulocyte differentiation; multicellular organismal development; cytokine and chemokine mediated signaling pathway; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of actin filament polymerization; positive regulation of cell proliferation; positive regulation of transcription factor import into nucleus; immune response; positive regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010] |
| UniProt Code: | P09919 |
| NCBI GenInfo Identifier: | 117564 |
| NCBI Gene ID: | 1440 |
| NCBI Accession: | P09919.1 |
| UniProt Secondary Accession: | P09919,A8MXR7, |
| UniProt Related Accession: | P09919 |
| Molecular Weight: | 18,434 Da |
| NCBI Full Name: | Granulocyte colony-stimulating factor |
| NCBI Synonym Full Names: | colony stimulating factor 3 (granulocyte) |
| NCBI Official Symbol: | CSF3�� |
| NCBI Official Synonym Symbols: | GCSF; CSF3OS; C17orf33�� |
| NCBI Protein Information: | granulocyte colony-stimulating factor; filgrastim; lenograstim; pluripoietin |
| UniProt Protein Name: | Granulocyte colony-stimulating factor |
| UniProt Synonym Protein Names: | Pluripoietin; INN: Filgrastim; INN: Lenograstim |
| Protein Family: | Granulocyte colony-stimulating factor |
| UniProt Gene Name: | CSF3�� |
| UniProt Entry Name: | CSF3_HUMAN |
