The MKS1 Polyclonal Antibody (CAB4802) is a powerful tool for research involving the MKS1 protein, a key player in ciliogenesis and ciliary function. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the MKS1 protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for studies in developmental biology and ciliopathy research.
MKS1 is a crucial component of the ciliary transition zone, involved in ciliary assembly and maintenance. Dysregulation of MKS1 has been linked to various ciliopathies, making it an important target for understanding the molecular mechanisms underlying these disorders. Research into MKS1 has the potential to uncover new therapeutic targets for ciliopathy treatments and advance our knowledge of ciliary biology.
Product Name:
MKS1 Rabbit Polyclonal Antibody
SKU:
CAB4802
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 150-300 of human MKS1 (NP_060247.2).
The protein encoded by this gene localizes to the basal body and is required for formation of the primary cilium in ciliated epithelial cells. Mutations in this gene result in Meckel syndrome type 1 and in Bardet-Biedl syndrome type 13. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
54903
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MKS1 antibody (CAB4802) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
