| UniProt Protein Function: | Mnk1: a CAM kinase of the MAPKKAPK family that can regulate translation. Following activation by MAP kinases, Mnk1 phosphorylates eIF4E at Ser209, increasing its affinity for the 7-methylguanosine-containing mRNA cap. Two MAPK phosphorylation sites in mouse Mnk1 (Thr197 and Thr202) are essential for its kinase activity. Three alternatively spliced human isoforms have been described. |
| UniProt Protein Details: | Protein type:EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Translation; Protein kinase, CAMK; CAMK group; MAPKAPK family; MNK subfamily Chromosomal Location of Human Ortholog: 1p33 Cellular Component: cytoplasm; cytosol; nucleoplasm Molecular Function:ATP binding; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; protein binding; protein serine/threonine kinase activity Biological Process: fibroblast growth factor receptor signaling pathway; peptidyl-serine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of translational initiation |
| NCBI Summary: | This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012] |
| UniProt Code: | Q9BUB5 |
| NCBI GenInfo Identifier: | 30316115 |
| NCBI Gene ID: | 8569 |
| NCBI Accession: | Q9BUB5.1 |
| UniProt Secondary Accession: | Q9BUB5,O00312, Q5TC06, Q5TC07, Q6V0N6, D3DQ20, D3DQ21 |
| UniProt Related Accession: | Q9BUB5 |
| Molecular Weight: | 39,104 Da |
| NCBI Full Name: | MAP kinase-interacting serine/threonine-protein kinase 1 |
| NCBI Synonym Full Names: | MAP kinase interacting serine/threonine kinase 1 |
| NCBI Official Symbol: | MKNK1 |
| NCBI Official Synonym Symbols: | MNK1 |
| NCBI Protein Information: | MAP kinase-interacting serine/threonine-protein kinase 1 |
| UniProt Protein Name: | MAP kinase-interacting serine/threonine-protein kinase 1 |
| UniProt Synonym Protein Names: | MAP kinase signal-integrating kinase 1; MAPK signal-integrating kinase 1; Mnk1 |
| Protein Family: | MAP kinase-interacting serine/threonine-protein kinase |
| UniProt Gene Name: | MKNK1 |
| UniProt Entry Name: | MKNK1_HUMAN |
