Description
| 抗体名: | MINPP1 Antibody (PACO22431) |
| 抗体コード: | PACO22431 |
| サイズ: | 100ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| 反応性: | Human |
| 免疫原: | Synthesized peptide derived from internal of human MINPP1. |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from 293 cells, using MINPP1 antibody. |
| バックグラウンド: | Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification). |
| シノニム: | EC 3.1.3.62; inositol (1; 3; 4; 5)-tetrakisphosphate 3-phosphatase |
| UniProt Protein Function: | MINPP1: Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3- phosphoglycerate. May play a role in bone development (endochondral ossification). Defects in MINPP1 may be involved in follicular thyroid tumors development. Belongs to the histidine acid phosphatase family. MINPP1 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.1.3.80; Hydrolase; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted; EC 3.1.3.62; Carbohydrate Metabolism - inositol phosphate Chromosomal Location of Human Ortholog: 10q23 Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen Molecular Function:acid phosphatase activity; phosphohistidine phosphatase activity Biological Process: bone mineralization; dephosphorylation; inositol phosphate metabolic process; ossification; polyphosphate metabolic process Disease: Thyroid Carcinoma, Follicular |
| NCBI Summary: | This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.[provided by RefSeq, Sep 2009] |
| UniProt Code: | Q9UNW1 |
| NCBI GenInfo Identifier: | 68565617 |
| NCBI Gene ID: | 9562 |
| NCBI Accession: | Q9UNW1.1 |
| UniProt Secondary Accession: | Q9UNW1,O95172, O95286, Q59EJ2, Q9UGA3, F5H683, |
| UniProt Related Accession: | Q9UNW1 |
| Molecular Weight: | 33,100 Da |
| NCBI Full Name: | Multiple inositol polyphosphate phosphatase 1 |
| NCBI Synonym Full Names: | multiple inositol-polyphosphate phosphatase 1 |
| NCBI Official Symbol: | MINPP1 |
| NCBI Official Synonym Symbols: | MIPP; HIPER1; MINPP2 |
| NCBI Protein Information: | multiple inositol polyphosphate phosphatase 1 |
| UniProt Protein Name: | Multiple inositol polyphosphate phosphatase 1 |
| UniProt Synonym Protein Names: | 2,3-bisphosphoglycerate 3-phosphatase (EC:3.1.3.80); 2,3-BPG phosphatase; Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase; Ins(1,3,4,5)P(4) 3-phosphatase |
| Protein Family: | Multiple inositol polyphosphate phosphatase |
| UniProt Gene Name: | MINPP1 |
| UniProt Entry Name: | MINP1_HUMAN |
