Description
| 抗体名: | MICU2 Antibody (PACO53490) |
| 抗体コード: | PACO53490 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Calcium uptake protein 2, mitochondrial protein (26-247AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO53490 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human lung cancer using PACO53490 at dilution of 1:100. |
| バックグラウンド: | Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium. MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering. |
| シノニム: | Calcium uptake protein 2, mitochondrial (EF-hand domain-containing family member A1), MICU2, EFHA1 |
| UniProt Protein Function: | MICU2: Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU). Component of a complex, at least composed of MCU, MICU1 and MICU2 |
| UniProt Protein Details: | Protein type:Calcium-binding; Mitochondrial Chromosomal Location of Human Ortholog: 13q12.11 Cellular Component: mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrion; nucleus Molecular Function:protein binding; protein heterodimerization activity Biological Process: mitochondrial calcium ion homeostasis; mitochondrial calcium ion transport; reduction of mitochondrial calcium ion concentration |
| UniProt Code: | Q8IYU8 |
| NCBI GenInfo Identifier: | 115502157 |
| NCBI Gene ID: | 221154 |
| NCBI Accession: | Q8IYU8.2 |
| UniProt Secondary Accession: | Q8IYU8,Q8N0T6, Q8NAX8, |
| UniProt Related Accession: | Q8IYU8 |
| Molecular Weight: | 50kDa |
| NCBI Full Name: | Calcium uptake protein 2, mitochondrial |
| NCBI Synonym Full Names: | mitochondrial calcium uptake 2 |
| NCBI Official Symbol: | MICU2 |
| NCBI Official Synonym Symbols: | EFHA1; 1110008L20Rik |
| NCBI Protein Information: | calcium uptake protein 2, mitochondrial |
| UniProt Protein Name: | Calcium uptake protein 2, mitochondrial |
| UniProt Synonym Protein Names: | EF-hand domain-containing family member A1 |
| Protein Family: | Calcium uptake protein |
| UniProt Gene Name: | MICU2 |
