| UniProt Protein Function: | MEF2B: Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle- specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription. Belongs to the MEF2 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 19p13.11 Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; cell junction; nucleus Molecular Function:protein dimerization activity; histone deacetylase binding; transcription factor activity Biological Process: muscle development; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene represents numerous read-through transcripts that span GeneID:729991 and 100271849. Many read-through transcripts are predicted to be nonsense-mediated decay (NMD) candidates, and are thought to be non-coding. Some transcripts are predicted to be capable of translation reinitiation at a downstream AUG, resulting in expression of at least one isoform of myocyte enhancer factor 2B (MEF2B) from this read-through locus. At least one additional MEF2B variant and isoform can be expressed from a downstream promoter, and is annotated on GeneID:100271849. [provided by RefSeq, Oct 2010] |
| UniProt Code: | Q02080 |
| NCBI GenInfo Identifier: | 5174543 |
| NCBI Gene ID: | 4207 |
| NCBI Accession: | NP_005910 |
| UniProt Related Accession: | Q02080 |
| Molecular Weight: | 39kDa |
| NCBI Full Name: | myocyte-specific enhancer factor 2B isoform b |
| NCBI Synonym Full Names: | BORCS8-MEF2B readthrough |
| NCBI Official Symbol: | BORCS8-MEF2B |
| NCBI Official Synonym Symbols: | MEF2B; RSRFR2; MEF2BNB-MEF2B; LOC729991-MEF2B |
| NCBI Protein Information: | myocyte-specific enhancer factor 2B |
| UniProt Protein Name: | Myocyte-specific enhancer factor 2B |
| UniProt Synonym Protein Names: | RSRFR2; Serum response factor-like protein 2 |
| Protein Family: | Myocyte-specific enhancer factor |
| UniProt Gene Name: | MEF2B |
| UniProt Entry Name: | MEF2B_HUMAN |
