Description
| 抗体名: | MED18 Antibody (PACO22404) |
| 抗体コード: | PACO22404 |
| サイズ: | 100ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| 反応性: | Human, Mouse |
| 免疫原: | Synthesized peptide derived from internal of human MED18. |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from Jurkat cells and COLO cells, using MED18 antibody. |
| バックグラウンド: | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. |
| シノニム: | FLJ20045; mediator 18; mediator of RNA polymerase II transcription 18; p28b; |
| UniProt Protein Function: | MED18: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 18 family. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 1p35.3 Cellular Component: Srb-mediator complex Molecular Function:protein binding Biological Process: termination of RNA polymerase II transcription |
| NCBI Summary: | MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008] |
| UniProt Code: | Q9BUE0 |
| NCBI GenInfo Identifier: | 74752353 |
| NCBI Gene ID: | 54797 |
| NCBI Accession: | Q9BUE0.1 |
| UniProt Secondary Accession: | Q9BUE0,Q9NXU9, D3DPM1, |
| UniProt Related Accession: | Q9BUE0 |
| Molecular Weight: | 23,663 Da |
| NCBI Full Name: | Mediator of RNA polymerase II transcription subunit 18 |
| NCBI Synonym Full Names: | mediator complex subunit 18 |
| NCBI Official Symbol: | MED18 |
| NCBI Official Synonym Symbols: | p28b |
| NCBI Protein Information: | mediator of RNA polymerase II transcription subunit 18 |
| UniProt Protein Name: | Mediator of RNA polymerase II transcription subunit 18 |
| UniProt Synonym Protein Names: | Mediator complex subunit 18; p28b |
| Protein Family: | Mediator of RNA polymerase II transcription |
| UniProt Gene Name: | MED18 |
| UniProt Entry Name: | MED18_HUMAN |
