| UniProt Protein Function: | MCM5: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Interacts with MCMBP. Belongs to the MCM family. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; EC 3.6.4.12 Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: nucleoplasm; MCM complex; membrane; nucleus Molecular Function:DNA helicase activity; protein binding; DNA binding; ATP binding Biological Process: DNA replication initiation; DNA strand elongation during DNA replication; mitotic cell cycle; DNA replication; DNA duplex unwinding; G1/S transition of mitotic cell cycle |
| NCBI Summary: | The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P33992 |
| NCBI GenInfo Identifier: | 19858646 |
| NCBI Gene ID: | 4174 |
| NCBI Accession: | P33992.5 |
| UniProt Secondary Accession: | P33992,O60785, Q14578, Q9BTJ4, Q9BWL8, |
| UniProt Related Accession: | P33992 |
| Molecular Weight: | 82,286 Da |
| NCBI Full Name: | DNA replication licensing factor MCM5 |
| NCBI Synonym Full Names: | minichromosome maintenance complex component 5 |
| NCBI Official Symbol: | MCM5 |
| NCBI Official Synonym Symbols: | CDC46; P1-CDC46 |
| NCBI Protein Information: | DNA replication licensing factor MCM5; CDC46 homolog; minichromosome maintenance deficient 5 (cell division cycle 46); MCM5 minichromosome maintenance deficient 5, cell division cycle 46 |
| UniProt Protein Name: | DNA replication licensing factor MCM5 |
| UniProt Synonym Protein Names: | CDC46 homolog; P1-CDC46 |
| Protein Family: | Minichromosome maintenance protein |
| UniProt Gene Name: | MCM5 |
| UniProt Entry Name: | MCM5_HUMAN |
