Description
| 抗体名: | MAP4K3 Antibody (PACO10373) |
| 抗体コード: | PACO10373 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Human MAP4K3 |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| 精製方法: | Antigen Affinity purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | mitogen-activated protein kinase kinase kinase kinase 3;MAP4K3;GLK;MAPKKKK3;RAB8IPL1 ; |
| UniProt Protein Function: | KHS2: an ubiquitous protein kinase of the STE20 family. May play a role in the response to environmental stress. Regulated by amino acids and acts upstream of mTORC1 and JNK. Required for maximal S6K and 4E-BP1 phosphorylation. Interacts with PPP2R5E, a regulatory subunit of PP2A. Following amino acid withdrawal, pS170 is dephosphorylated via PP2A. The dephosphorylation of pS170 by PP2A in response to amino acid restriction inhibits mTORC1 signaling. The inhibition of PPP2R5E expression prevents the dephosphorylation of KHS2 pS170, impairing mTORC1 inhibition during amino acid withdrawal. Three alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; STE group; STE20 family; KHS subfamily Chromosomal Location of Human Ortholog: 2p22.1 Cellular Component: cytoplasm Molecular Function:protein serine/threonine kinase activity; protein binding; ATP binding; protein kinase activity; receptor signaling protein serine/threonine kinase activity Biological Process: regulation of catalytic activity; JNK cascade; protein amino acid phosphorylation; response to UV |
| NCBI Summary: | This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] |
| UniProt Code: | Q8IVH8 |
| NCBI GenInfo Identifier: | 29427817 |
| NCBI Gene ID: | 8491 |
| NCBI Accession: | Q8IVH8.1 |
| UniProt Secondary Accession: | Q8IVH8,Q6IQ39, Q8IVH7, Q9UDM5, Q9Y6R5, |
| UniProt Related Accession: | Q8IVH8 |
| Molecular Weight: | Observed MW: 110kDaCalculated MW: 98kDa/100kDa/101kDa |
| NCBI Full Name: | Mitogen-activated protein kinase kinase kinase kinase 3 |
| NCBI Synonym Full Names: | mitogen-activated protein kinase kinase kinase kinase 3 |
| NCBI Official Symbol: | MAP4K3 |
| NCBI Official Synonym Symbols: | GLK; MEKKK3; MEKKK 3; MAPKKKK3; RAB8IPL1 |
| NCBI Protein Information: | mitogen-activated protein kinase kinase kinase kinase 3; MEK kinase kinase 3; MAPK/ERK kinase kinase kinase 3; germinal center kinase-like kinase; germinal center kinase-related protein kinase |
| UniProt Protein Name: | Mitogen-activated protein kinase kinase kinase kinase 3 |
| UniProt Synonym Protein Names: | Germinal center kinase-related protein kinase; GLK; MAPK/ERK kinase kinase kinase 3; MEK kinase kinase 3; MEKKK 3 |
| Protein Family: | Mitogen-activated protein kinase kinase kinase kinase |
| UniProt Gene Name: | MAP4K3 |
| UniProt Entry Name: | M4K3_HUMAN |
