Description
| 抗体名: | MAN1B1 Antibody (PACO22327) |
| 抗体コード: | PACO22327 |
| サイズ: | 100ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| 反応性: | Human |
| 免疫原: | Synthesized peptide derived from internal of human MAN1B1. |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from 3T3 cells, using MAN1B1 antibody. |
| バックグラウンド: | Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man9GlcNAc2 to produce Man8GlcNAc2, but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man5-6GlcNAc2. |
| シノニム: | Endoplasmic reticulum mannosyl-oligosaccharide 1; 2-alpha-mannosidase; EC=3.2.1.113; ER alpha-1; 2-mannosidase |
| UniProt Protein Function: | MAN1B1: Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2). Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Belongs to the glycosyl hydrolase 47 family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; EC 3.2.1.113; Hydrolase; Glycan Metabolism - N-glycan biosynthesis; Endoplasmic reticulum; Calcium-binding Chromosomal Location of Human Ortholog: 9q34 Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane; vesicle Molecular Function:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; calcium ion binding Biological Process: ER-associated protein catabolic process; cellular protein metabolic process; protein folding; protein amino acid N-linked glycosylation; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; oligosaccharide metabolic process Disease: Mental Retardation, Autosomal Recessive 15 |
| UniProt Code: | Q9UKM7 |
| NCBI GenInfo Identifier: | 218749883 |
| NCBI Gene ID: | 11253 |
| NCBI Accession: | NP_057303 |
| UniProt Secondary Accession: | Q9UKM7,Q5VSG3, Q9BRS9, Q9Y5K7, |
| UniProt Related Accession: | Q9UKM7 |
| Molecular Weight: | 79,580 Da |
| NCBI Full Name: | endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase |
| NCBI Synonym Full Names: | mannosidase, alpha, class 1B, member 1 |
| NCBI Official Symbol: | MAN1B1 |
| NCBI Official Synonym Symbols: | MRT15; ERMAN1; MANA-ER |
| NCBI Protein Information: | endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; ER alpha 1,2-mannosidase; Man9GlcNAc2-specific processing alpha-mannosidase; endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase 1 |
| UniProt Protein Name: | Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase |
| UniProt Synonym Protein Names: | ER alpha-1,2-mannosidase; ER mannosidase 1; ERMan1; Man9GlcNAc2-specific-processing alpha-mannosidase; Mannosidase alpha class 1B member 1 |
| Protein Family: | Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase |
| UniProt Gene Name: | MAN1B1 |
| UniProt Entry Name: | MA1B1_HUMAN |
